PIM-447 dihydrochloride (Synonyms: LGH447 dihydrochloride) |
| Catalog No.GC36918 |
Le dichlorhydrate de PIM447 (dichlorhydrate de LGH447) est un inhibiteur de pan-PIM kinase puissant, disponible par voie orale et sélectif, avec des valeurs de Ki de 6, 18 et 9 pM pour PIM1, PIM2 et PIM3, respectivement. Le dichlorhydrate de PIM447 présente un double effet antimyélome et protecteur des os. Le dichlorhydrate de PIM447 induit l'apoptose.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1820565-69-2
Sample solution is provided at 25 µL, 10mM.
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PIM447 is a pan-PIM kinase ihibitor with Kis of 6, 18, 9 nM for PIM1, PIM2 and PIM3, respectively.
[1]. PaÍno T et al. The novel pan-PIM kinase inhibitor, PIM447, displays dual anti-myeloma and bone protective effects, and potently synergizes with current standards of care. Clin Cancer Res. 2016 Jul 20. [2]. Burger MT et al. Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies. J Med Chem. 2015 Nov 12;58(21):8373-86. [3]. Peters TL et al. Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447.Oncotarget. 2016 Aug 20
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