1,3-Dipalmitoyl-rac-glycerol is a diacylglycerol that contains palmitic acid at the sn-1 and sn-3 positions. It activates protein kinase C α (PKCα) in vitro (Ka = 3.8 μM).1 1,3-Dipalmitoyl-rac-glycerol (0.25-2 μM) inhibits apoptosis and production of reactive oxygen species (ROS) and pro-inflammatory mediators induced by oxygen-glucose deprivation and reperfusion (OGD/R) in SH-SY5Y neuroblastoma cells.2
References
1. SÁnchez-Pi•era, P., Micol, V., CorbalÁn-GarcÍa, S., et al. A comparative study of the activation of protein kinase C α by different diacylglycerol isomers. Biochem. J. 337(3), 387-395 (1999).
2. Cheng, M.-C., and Pan, T.-M. Glyceryl 1,3-dipalmitate produced from Lactobacillus paracasei subspecies. paracasei NTU 101 inhibits oxygen-glucose deprivation and reperfusion-induced oxidative stress via upregulation of peroxisome proliferator-activated receptor γ in neuronal SH-SY5Y cells. J. Agric. Food Chem. 65(36), 7926-7933 (2017).