Histone H3K9Me1 (3-17) is a peptide fragment of histone H3 that corresponds to amino acid residues 4-18 of the human histone H3 sequence. Monomethylation of histone H3 at lysine 9 is found at euchromatin regions of silenced genes and is correlated with gene repression.1 Recognition of H3K9Me1 by the H3K9 demethylases GLP and G9a is essential to embryonic stem cell differentiation and viability in mice.2 Cytoplasmic expression of H3K9Me1 is associated with reduced disease-specific mortality risk in patients with oral and/or oropharyngeal squamous cell carcinoma.3
References
1. Gupta, J., Kumar, S., Li, J., et al. Histone H3 lysine 4 monomethylation (H3K4me1) and H3 lysine 9 monomethylation (H3K9me1): Distribution and their association in regulating gene expression under hyperglycaemic/hyperinsulinemic conditions in 3T3 cells. Biochimie 94(12), 2656-2664 (2012).
2. Liu, N., Zhang, Z., Wu, H., et al. Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability. Genes Dev. 29(4), 379-393 (2015).
3. Maia, L.L., Peterle, G.T., Dos Santos, M., et al. JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma. PLoS One 13(3), e019884 (2018).