GPP 78 (Synonyms: CAY10618, NMPRTase Inhibitor) |
| Catalog No.GC41308 |
Le GPP 78 (CAY10618) est un puissant inhibiteur de Nampt avec une IC50 de 3,0 nM pour la déplétion du nicotinamide adénine dinucléotide (NAD).
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Cas No.: 1202580-59-3
Sample solution is provided at 25 µL, 10mM.
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Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide into nicotinamide mononucleotide (NMN), which is subsequently converted to NAD+ by NMN adenyltransferase. Cancer cells commonly have an unusually high rate of NAD+ turnover, suggesting that inhibition of Nampt might selectively target cancer cells. GPP 78 is a potent inhibitor of Nampt (IC50 = 3 nM). It induces cell death in the neuroblastoma cell line SH-SY5Y with an IC50 value of 3.8 nM through a process that appears to involve autophagy.
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