GSK9311 |
| Catalog No.GC33324 |
Le GSK9311, un analogue moins actif du GSK6853, peut être utilisé comme témoin négatif. GSK9311 inhibe le bromodomaine BRPF avec des valeurs de pIC50 de 6,0 et 4,3 pour BRPF1 et BRPF2, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1923851-49-3
Sample solution is provided at 25 µL, 10mM.
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GSK9311 is a potent inhibitor of the BRPF bromodomain with pIC50 values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively.
GSK6853 is a potent (300 pM), soluble, cell active (20 nM), and highly selective inhibitor of the BRPF1 bromodomain, and demonstrates properties suitable for cellular and in vivo studies. GSK6853 is a less active analogue of GSK6853 in which the 5-amide is alkylated[1].
[1]. Bamborough P, et al. GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain. ACS Med Chem Lett. 2016 May 9;7(6):552-7.
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