Imatinib D4 |
| Catalog No.GC60930 |
Imatinib D4 (STI571 D4) est un imatinib marqué au deutérium (STI571). L'imatinib est un inhibiteur des tyrosine kinases biodisponible par voie orale qui inhibe sélectivement l'activité de BCR/ABL, v-Abl, PDGFR et c-kit kinase.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1134803-16-9
Sample solution is provided at 25 µL, 10mM.
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Imatinib D4 (STI571 D4) is a deuterium labeled Imatinib (STI571). Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity[1][2].
[1]. Heinrich MC, et al. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood. 2000 Aug 1;96(3):925-32. [2]. Guida T, et al. Sorafenib inhibits imatinib-resistant KIT and platelet-derived growth factor receptor beta gatekeeper mutants. Clin Cancer Res. 2007 Jun 1;13(11):3363-9. [3]. Coleman CM, et al, Frieman MB. Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion. J Virol. 2016;90(19):8924‐8933. Published 2016 Sep 12.
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