KR-33493 |
Catalog No.GC19214 |
Le KR-33493 est un puissant inhibiteur de la mort cellulaire médiée par Fas (FAF1).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1021497-97-1
Sample solution is provided at 25 µL, 10mM.
KR-33493 is a potent inhibitor of Fas-mediated cell death (FAF1).
Body weight changes of both sexes are not related to KR-33493 in all doses. In rats administrated KR-33493 for 4 weeks, no test article-related changes in any treated groups of either sex are found in hematology, serum biochemistry, and urinalysis. In dogs administrated KR-33493 for 2 weeks, red blood cell count (RBC) value in males is significantly higher at the 1000 mg/kg/day dose than that of the control group (i.e., 6.96±0.323 vs. 6.12±0.418). However, the change of RBC is recovered after the end of the administration period. The dose-normalized AUClast is not significantly different between the groups, suggesting that KR-33493 is governed by linear kinetics[1].
References:
[1]. Jeong JW, et al. Subacute toxicity evaluation of KR-33493, FAF1 inhibitor for a new anti-parkinson's disease agent, after oral administration in rats and dogs. Regul Toxicol Pharmacol. 2016 Nov;81:387-396.
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