Momilactone A is a naturally derived diterpene lactone with multiple biological activities including anticancer, antibacterial and antioxidant properties. Momilactone A inhibits inflammatory responses by reducing NO production and iNOS expression. Momilactone A acts as a corrosion inhibitor for mild steel; it forms an isolating film on the metal surface via adsorption between oxygen atoms of the molecule and iron ions, thereby blocking corrosive media. Momilactone A inhibits the growth of fungal and bacterial organisms, and also functions as an allelochemical to inhibit the growth of adjacent competing plants. Momilactone A can be used in studies related to leukemia, fungal infections and bacterial infections [1] [2] [3].
In Vitro, Momilactone A (MA) (0.5-10 μM; 48 h) exhibits only mild cytotoxicity toward non-cancerous MeT-5A cells, and shows weak cytotoxicity toward both acute promyelocytic leukemia HL-60 cells and multiple myeloma U266 cells[1]. Momilactone A inhibits the corrosion of mild steel in 1 M HCl by adsorbing at the metal-solution interface, and reduces the formation of iron oxide on the surface of mild steel immersed in 1 M HCl for 3 h[2]. Momilactone A inhibits phytopathogenic fungi such as Magnaporthe oryzae, as well as common soil bacteria and human-associated bacteria[3]. Momilactone A inhibits the inflammatory response of mouse macrophage RAW264.7 by reducing NO production and iNOS mRNA expression[3].
References:
[1]. Anh H, et al. Cytotoxic Mechanism of Momilactones A and B against Acute Promyelocytic Leukemia and Multiple Myeloma Cell Lines. Cancers. 2022 Oct 04;14(19):4848.
[2]. Prabakaran M, et al. Anticorrosion properties of momilactone A isolated from rice hulls. Journal of Industrial and Engineering Chemistry, 2017, 45: 380-386.
[3]. Kato-Noguchi H, et al. Defensive Molecules Momilactones A and B: Function, Biosynthesis, Induction and Occurrence. Toxins. 2023 Mar 25;15(4):241.
In Vitro, Momilactone A (MA) (0.5-10 μM; 48 h) exhibits only mild cytotoxicity toward non-cancerous MeT-5A cells, and shows weak cytotoxicity toward both acute promyelocytic leukemia HL-60 cells and multiple myeloma U266 cells[1]. Momilactone A inhibits the corrosion of mild steel in 1 M HCl by adsorbing at the metal-solution interface, and reduces the formation of iron oxide on the surface of mild steel immersed in 1 M HCl for 3 h[2]. Momilactone A inhibits phytopathogenic fungi such as Magnaporthe oryzae, as well as common soil bacteria and human-associated bacteria[3]. Momilactone A inhibits the inflammatory response of mouse macrophage RAW264.7 by reducing NO production and iNOS mRNA expression[3].
References:
[1]. Anh H, et al. Cytotoxic Mechanism of Momilactones A and B against Acute Promyelocytic Leukemia and Multiple Myeloma Cell Lines. Cancers. 2022 Oct 04;14(19):4848.
[2]. Prabakaran M, et al. Anticorrosion properties of momilactone A isolated from rice hulls. Journal of Industrial and Engineering Chemistry, 2017, 45: 380-386.
[3]. Kato-Noguchi H, et al. Defensive Molecules Momilactones A and B: Function, Biosynthesis, Induction and Occurrence. Toxins. 2023 Mar 25;15(4):241.