Nerolidol

Nerolidol is a sesquiterpene found in a variety of plants, including C. sativa, that has diverse biological activities, including antioxidant, anthelmintic, antinociceptive, and anti-inflammatory properties. It decreases superoxide dismutase (SOD) and catalase activity, reduces glutathione (GSH) levels, and increases malondialdehyde (MDA) levels in the brain when administered at a dose of 50 mg/kg in a rat model of Parkinson's disease induced by rotenone . It also inhibits rotenone-induced increases in IL-1β, IL-6, and TNF-α in rat brain. Nerolidol (100, 200, and 400 mg/kg) reduces worm burden and egg production in a mouse model of schistosomiasis. It also decreases acetic acid-induced writhing and formalin-induced licking time in mice, indicating antinociceptive activity, and reduced carrageenan-induced paw edema when administered at doses of 300 and 400 mg/kg. Formulations containing nerolidol have been used as fragrance ingredients.