PF-06840003 (EOS200271) (Synonyms: PF-06840003) |
Catalog No.GC32879
One-Click Copy Product Info
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PF-06840003 (EOS200271) (EOS200271) est un inhibiteur d'IDO-1 hautement sélectif et biodisponible par voie orale avec des IC50 de 0,41 μM, 0,59 μM et 1,5 μM pour hIDO-1, et d , respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 198474-05-4
Sample solution is provided at 25 µL, 10mM.
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PF-06840003 is a highly selective orally bioavailable IDO-1 inhibitor.
PF-06840003 reverses IDO-1-induced T-cell anergy in vitro[1].
PF-06840003 reduces intratumoral kynurenine levels in mice by >80% and inhibits tumor growth in multiple preclinical syngeneic models in mice, in combination with immune checkpoint inhibitors. PF-0684003 has favorable predicted human pharmacokinetic properties, including a predicted t1/2 of 16-19 hours[1].
[1]. Tumang J, et al. PF-06840003: a highly selective IDO-1 inhibitor that shows good in vivo efficacy in combination with immune checkpoint inhibitors. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr4863.
| Cas No. | 198474-05-4 | SDF | |
| Synonymes | PF-06840003 | ||
| Canonical SMILES | O=C(C(C1=CNC2=C1C=C(F)C=C2)C3)NC3=O | ||
| Formula | C12H9FN2O2 | M.Wt | 232.21 |
| Solubility | DMSO : ≥ 28 mg/mL (120.58 mM) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.3064 mL | 21.5322 mL | 43.0645 mL |
| 5 mM | 861.3 μL | 4.3064 mL | 8.6129 mL |
| 10 mM | 430.6 μL | 2.1532 mL | 4.3064 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)