PLX-4104 |
Catalog No.GC80929
One-Click Copy Product Info
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PLX-4104 is an orally active BRD4 molecular glue degrader with a DC50 of 2 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2851986-77-9
Sample solution is provided at 25 µL, 10mM.
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In Vivo, PLX-4104 (2-6 mg/kg; p.o.; daily; 21 days) elicits dose-dependent antitumor efficacy in AML MV-4-11 xenografts without significant body weight changes[1].
In Vitro, PLX-4104 potently binds to BRD4 with an IC50 of 4 nM[1]. PLX-4104 (24 h) induces near-complete (>95%) BRD4 degradation in MV-4-11 cells with a DC50 of 2 nM[1]. PLX-4104 (72 h) potently inhibits the proliferation of MV-4-11 cells with an EC50 of 4 nM[1]. PLX-4104 has intrinsic clearance of 11.1 mL/min/kg in human liver microsomes and <10 mL/min/kg in mouse liver microsomes[1].
References:
[1]. Leriche G, et al. Discovery and Structural Optimization of BRD4-Selective Monovalent Direct Degraders[J]. ACS Medicinal Chemistry Letters, 2026.
| Cas No. | 2851986-77-9 | SDF | |
| Formula | C32H26FN9O2S | M.Wt | 619.67 |
| Solubility | DMSO: 100 mg/mL (161.38 mM; Need ultrasonic) | Storage | Store at -20°C |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.6138 mL | 8.0688 mL | 16.1376 mL |
| 5 mM | 322.8 μL | 1.6138 mL | 3.2275 mL |
| 10 mM | 161.4 μL | 806.9 μL | 1.6138 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)