ADC Cytotoxin
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ADC Cytotoxin are a large collection of toxins for antibody-drug conjugate (ADC) development projects. The toxins that can be used as payloads should be soluble, amenable to conjugation, and stable. There are myriads of cellular toxins in natural or synthesized, but only a few have been found adaptable for an ADC concept.
The toxins targeting tubulin filaments include Maytansinoids, Auristatins, Taxol derivatives, etc. Amatoxins are a class of transcription-inhibiting agents. They bind to RNA polymerase II, leading to cell apoptosis. Protein toxins function in the similar MOA (mechanism of action) with cellular toxins, they could inhibit protein synthesis and induce cell death. While enzyme-based ADCs alter the microenvironment of disease tissues to disturb their functions.
Products Related to ADC Cytotoxin(111)
- GC69091Exatecan Intermediate 2CAS: 182182-31-6Purity: >99.00%
Exatecan Intermediate 2 (composé B) is an intermediate of Exatecan (DX-8951). Exatecan is an anticancer agent belonging to the camptothecin analogs. It interferes with tumor cell proliferation and division by interacting with DNA, thereby inhibiting tumor growth. Exatecan is mainly used in research on various cancers such as ovarian cancer, lung cancer, and breast cancer.
- GC69278InebilizumabCAS: 1299440-37-1Purity: >95.00%
Inebilizumab is a monoclonal antibody (mAb) that targets CD19 and enhances antibody-dependent cell-mediated cytotoxicity against B cells. Inebilizumab is being studied for use in multiple sclerosis and neuromyelitis optica spectrum disorder.
- GC69438Maytansinoid BCAS: 1628543-40-7Purity: >98%
Maytansinoid B is a type of ADC cytotoxin that can form Antibody-Drug Conjugates (ADCs) when coupled with antibodies. Maytansinoids are known anti-mitotic agents that bind to microtubules and inhibit their assembly. Maytansinoids can induce cell cycle arrest at G2/M phase, thereby inducing apoptosis.
- GC70043Tomaymycin DMCAS: 945490-09-5Purity: >98%
Tomaymycin DM is a DNA alkylating agent, a derivative of Tomaymycin and a monomer of PBD, which can serve as an effective payload for tumor-targeting antibody-drug conjugates (ADCs).
- GC71030Glucocorticoid receptor agonist-2CAS: 2166378-92-1Purity: >99.00%
Glucocorticoid receptor agonist-2 (composé 21) est un agoniste des récepteurs des glucocorticoïdes avec une valeur de ci50 de 6,6 nM.
- GC71458Glucocorticoid receptor agonist-3CAS: 2842165-73-3Purity: >98.00%
Glucocorticoid receptor agonist-3 (préparation 6) est un agoniste des récepteurs des glucocorticoïdes.
- GC730137-Aminomethyl-10-methyl-11-fluoro camptothecinCAS: 2378616-23-8Purity: >99.00%
7-Aminomethyl-10-methyl-11-fluoro camptothecin est une cytotoxine de MC - AA - nhch2och2coo - 7 - aminométhyl - 10 - metl - 11 - fluorochlorine.
- GC730147-Aminomethyl-10-methyl-11-fluoro camptothecin TFAPurity: >96.00%
7-Aminomethyl-10-methyl-11-fluoro camptothecin TFA est une cytotoxine de MC-AAA-NHCH2OCH2COO-7-aminometl-10-metl-11-fluoro camptothecin.
- GC730157-MAD-MDCPTCAS: 765871-81-6Purity: >98.00%
7-MAD-MDCPT Les analogues de la camphrine sont des charges utiles de toxines dans les coupleurs anticorps - médicaments (ADC).
- GC73056(1S,9R)-Exatecan mesylateCAS: 2938875-54-6Purity: >98.00%
(1S,9R)-Exatecan mesylate 1S, 9r - dx8951f est un isomère de l'acide méthanesulfonique exatecan.
- GC73057(1R,9R)-Exatecan mesylateCAS: 2938875-39-7Purity: >99.00%
(1R,9R)-Exatecan mesylate 1R, 9r - dx8951f est un isomère de l'acide méthanesulfonique exatecan.
- GC73204NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloridePurity: >95.00%
NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride est un inhibiteur de la topoisomérase I qui peut être livré aux cellules de manière ciblée par des anticorps couplés avec une bonne activité ADC in vivo et in vitro.
- GC73419Decyclohexanamine-ExatecanCAS: 2505045-51-0Purity: >98.00%
Decyclohexanamine-Exatecan est un dérivé de la camphrine, composé a, extrait du brevet wo2020219287 A1.
- GC736547-Hydroxyethyl carbamate-(10Me-11F-Camptothecin)CAS: 2873460-17-2Purity: >98.00%
7-Hydroxyethyl carbamate-(10Me-11F-Camptothecin) est un analogue de Camptothecin.
- GC73669Cyclopropaneacetamide-ExatecanCAS: 2414254-36-5Purity: >97.00%
Cyclopropaneacetamide-Exatecan (composé 2 - a) est une cytotoxine ADC et un analogue d'exatecan.
- GC73670(αR)-Cyclopropaneacetamide-ExatecanCAS: 2414254-37-6Purity: >99.00%
(αR)-Cyclopropaneacetamide-Exatecan Le composé 2 - A est un dérivé de l'exétican et un médicament cytotoxique.
- GC73685NH2-methylpropanamide-Exatecan TFACAS: 1817857-35-4
NH2-methylpropanamide-Exatecan TFA est un exatecan modifié par le mépropionamide, une cytotoxine ADC couramment utilisée dans la synthèse de l'ADC.
- GC736947-Hydroxymethyl-10,11-MDCPT-d5Purity: >97.00%
7-Hydroxymethyl-10,11-MDCPT-d5 est le 7 - hydroxyméthyl - 10,11 - mdcpt marqué au deutérium, qui est une charge utile qui peut être utilisée dans la synthèse ADC.
- GC73711Exatecan-methylacetamide-OHCAS: 2594423-51-3Purity: >97.00%
Exatecan-methylacetamide-OH (composé 6) est un dérivé d'exatecan ayant des effets anticancéreux.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC69091 | Exatecan Intermediate 2 | 182182-31-6 | >99.00% | |
Exatecan Intermediate 2 (composé B) is an intermediate of Exatecan (DX-8951). Exatecan is an anticancer agent belonging to the camptothecin analogs. It interferes with tumor cell proliferation and division by interacting with DNA, thereby inhibiting tumor growth. Exatecan is mainly used in research on various cancers such as ovarian cancer, lung cancer, and breast cancer. | ||||
| GC69278 | Inebilizumab | 1299440-37-1 | >95.00% | |
Inebilizumab is a monoclonal antibody (mAb) that targets CD19 and enhances antibody-dependent cell-mediated cytotoxicity against B cells. Inebilizumab is being studied for use in multiple sclerosis and neuromyelitis optica spectrum disorder. | ||||
| GC69438 | Maytansinoid B | 1628543-40-7 | >98% | |
Maytansinoid B is a type of ADC cytotoxin that can form Antibody-Drug Conjugates (ADCs) when coupled with antibodies. Maytansinoids are known anti-mitotic agents that bind to microtubules and inhibit their assembly. Maytansinoids can induce cell cycle arrest at G2/M phase, thereby inducing apoptosis. | ||||
| GC69863 | SC209 | 1977557-86-0 | >99.00% | |
SC209 est une toxine cellulaire ADC dérivée du brevet WO2021247798, utilisée pour synthétiser un ADC couplant des anticorps anti-EGFR à des molécules actives. SC209 est le métabolite de STRO-002. | ||||
| GC70043 | Tomaymycin DM | 945490-09-5 | >98% | |
Tomaymycin DM is a DNA alkylating agent, a derivative of Tomaymycin and a monomer of PBD, which can serve as an effective payload for tumor-targeting antibody-drug conjugates (ADCs). | ||||
| GC71030 | Glucocorticoid receptor agonist-2 | 2166378-92-1 | >99.00% | |
Glucocorticoid receptor agonist-2 (composé 21) est un agoniste des récepteurs des glucocorticoïdes avec une valeur de ci50 de 6,6 nM. | ||||
| GC71057 | S-Me-DM4 | 890654-03-2 | >99.00% | |
S-Me-DM4 est un métabolite de DM4 s-méthylé par l’enzyme intracellulaire. | ||||
| GC71458 | Glucocorticoid receptor agonist-3 | 2842165-73-3 | >98.00% | |
Glucocorticoid receptor agonist-3 (préparation 6) est un agoniste des récepteurs des glucocorticoïdes. | ||||
| GC73013 | 7-Aminomethyl-10-methyl-11-fluoro camptothecin | 2378616-23-8 | >99.00% | |
7-Aminomethyl-10-methyl-11-fluoro camptothecin est une cytotoxine de MC - AA - nhch2och2coo - 7 - aminométhyl - 10 - metl - 11 - fluorochlorine. | ||||
| GC73014 | 7-Aminomethyl-10-methyl-11-fluoro camptothecin TFA | - | >96.00% | |
7-Aminomethyl-10-methyl-11-fluoro camptothecin TFA est une cytotoxine de MC-AAA-NHCH2OCH2COO-7-aminometl-10-metl-11-fluoro camptothecin. | ||||
| GC73015 | 7-MAD-MDCPT | 765871-81-6 | >98.00% | |
7-MAD-MDCPT Les analogues de la camphrine sont des charges utiles de toxines dans les coupleurs anticorps - médicaments (ADC). | ||||
| GC73056 | (1S,9R)-Exatecan mesylate | 2938875-54-6 | >98.00% | |
(1S,9R)-Exatecan mesylate 1S, 9r - dx8951f est un isomère de l'acide méthanesulfonique exatecan. | ||||
| GC73057 | (1R,9R)-Exatecan mesylate | 2938875-39-7 | >99.00% | |
(1R,9R)-Exatecan mesylate 1R, 9r - dx8951f est un isomère de l'acide méthanesulfonique exatecan. | ||||
| GC73154 | TAM470 | 1802498-63-0 | >98.00% | |
TAM470 est une nouvelle cytolysine, inhibant la polymérisation tubuline et la dépolymérisation de microtubules. | ||||
| GC73204 | NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride | - | >95.00% | |
NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride est un inhibiteur de la topoisomérase I qui peut être livré aux cellules de manière ciblée par des anticorps couplés avec une bonne activité ADC in vivo et in vitro. | ||||
| GC73419 | Decyclohexanamine-Exatecan | 2505045-51-0 | >98.00% | |
Decyclohexanamine-Exatecan est un dérivé de la camphrine, composé a, extrait du brevet wo2020219287 A1. | ||||
| GC73622 | MMAF-OtBu | 745017-95-2 | - | |
MMAF-OtBu (exemple 2) est un CGRM modifié. | ||||
| GC73654 | 7-Hydroxyethyl carbamate-(10Me-11F-Camptothecin) | 2873460-17-2 | >98.00% | |
7-Hydroxyethyl carbamate-(10Me-11F-Camptothecin) est un analogue de Camptothecin. | ||||
| GC73669 | Cyclopropaneacetamide-Exatecan | 2414254-36-5 | >97.00% | |
Cyclopropaneacetamide-Exatecan (composé 2 - a) est une cytotoxine ADC et un analogue d'exatecan. | ||||
| GC73670 | (αR)-Cyclopropaneacetamide-Exatecan | 2414254-37-6 | >99.00% | |
(αR)-Cyclopropaneacetamide-Exatecan Le composé 2 - A est un dérivé de l'exétican et un médicament cytotoxique. | ||||
| GC73685 | NH2-methylpropanamide-Exatecan TFA | 1817857-35-4 | - | |
NH2-methylpropanamide-Exatecan TFA est un exatecan modifié par le mépropionamide, une cytotoxine ADC couramment utilisée dans la synthèse de l'ADC. | ||||
| GC73694 | 7-Hydroxymethyl-10,11-MDCPT-d5 | - | >97.00% | |
7-Hydroxymethyl-10,11-MDCPT-d5 est le 7 - hydroxyméthyl - 10,11 - mdcpt marqué au deutérium, qui est une charge utile qui peut être utilisée dans la synthèse ADC. | ||||
| GC73711 | Exatecan-methylacetamide-OH | 2594423-51-3 | >97.00% | |
Exatecan-methylacetamide-OH (composé 6) est un dérivé d'exatecan ayant des effets anticancéreux. | ||||
| GC73713 | FL118-14-Propanol | 2821768-98-1 | >98.00% | |
FL118-14-Propanol est un dérivé FL118. | ||||