Innate Immunity

Arachidic acid is a long-chain saturated fatty acid that has been found in peanut butter and anaerobic fungi.

Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of PI at the three position to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3.

AUY954 is an orally bioavailable and selective agonist of the sphingosine-1-phosphate receptor 1 (S1P1; EC50 = 1.2 nM for stimulating GTPγS binding to S1P1 in CHO cells).

Avenanthramide-C methyl ester is an inhibitor of NF-κB activation that acts by blocking the phosphorylation of IKK and IκB (IC50 ~ 40 μM).

Azido-FTY720 est un analogue photoactivable du FTY720.

BAY 61-3606 (hydrochloride) is a potent and selective inhibitor of Syk kinase with a K i value of 7.5nM.

La bertéroÏne, un analogue naturel du sulforaphane, est un agent antimétastatique.

BMS 345541 is a cell permeable inhibitor of the IκB kinases IKKα and IKKβ (IC50s = 4 and 0.3 μM).

BMS 470539 (hydrochloride) est un agoniste du récepteur mélanocortine-1 (MC-1R) hautement sélectif et puissant. Dans les dosages d'accumulation d' AMP cyclique (cAMP), ses valeurs d'EC50 sont respectivement 16.8 et 11.6nM pour MC1R humain et murin.

C16 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from C16 lactosylceramide.

C18 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from lactosylceramide.

C24:1 3'-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids.

Le campestanol est un phytostérol présent dans les aliments végétaux.

CAY10575 (Composé 8) est un inhibiteur de IKK2 avec une IC50 de 0,075 μM.

The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2.

L'inhibiteur de Chk2 (composé 1) est un inhibiteur puissant et sélectif de la kinase de point de contrÔle 2 (Chk2), avec des IC50 de 13,5 nM et 220,4 nM pour Chk2 et Chk1, respectivement. L'inhibiteur de Chk2 peut provoquer un fort effet de radioprotection médié par Chk2 dépendant de l'ataxie télangiectasie (ATM).

Chloramphenicol succinate is a water-soluble prodrug form of the antibiotic chloramphenicol.

Corticostatin is a corticostatic peptide that has been found in human granulocytes.

CPI-268456 (compos&eacute; 141) est un puissant inhibiteur de BRD4 avec une IC50 <0,5 μM.

Cromolyn is a chromone complex that acts as a mast cell stabilizer, preventing the release of histamine.

C-Type natriuretic peptide-22 (CNP-22) is an endogenous peptide with diverse biological activities.

Cyclic di-IMP (sodium salt) (c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP and cyclic di-AMP.

Deethylindanomycin is a polyether antibiotic that has been found in S.

Defensin HNP-1 is a peptide secreted by polymorphonuclear leukocytes (PMNs) that has antimicrobial properties.