SAFit1 |
| Catalog No.GC33699 |
SAFit1 est un inhibiteur spécifique de la protéine de liaison FK506 51 (FKBP51) avec un Ki de 4 ± 0,3 nM .
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1643125-32-9
Sample solution is provided at 25 µL, 10mM.
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SAFit1 is a FK506 binding protein 51 (FKBP51)-specific inhibitor with a Ki of 4±0.3 nM[1][2].
SAFit1 (1-1000 nM) potently stimulates neurite outgrowth in two neuronal cell lines (N2a and SH-SY5Y) as well as in primary hippocampal neurons. SAFit1 is active over a wide concentration range[1].
[1]. Gaali S, et al. Selective inhibitors of the FK506-binding protein 51 by induced fit. Nat Chem Biol. 2015 Jan;11(1):33-7. [2]. Sidibeh CO, et al. FKBP5 expression in human adipose tissue: potential role in glucose and lipid metabolism, adipogenesis and type 2 diabetes. Endocrine. 2018 Oct;62(1):116-128.
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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