Verucerfont |
| Catalog No.GC19374 |
Verucerfont est un antagoniste du récepteur 1 du facteur de libération de la corticotropine (CRF1) avec des CI50 d'environ 6,1, > 1 000 et > 1 000 nM pour CRF1, CRF2 et CRF-BP, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 885220-61-1
Sample solution is provided at 25 µL, 10mM.
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Verucerfont is a corticotropin-releasing factor receptor 1 (CRF1) antagonist with IC50s of ~6.1, >1000 and >1000 nM for CRF1, CRF2, and CRF-BP, respectively.
Post hoc analysis shows that the prototypic non-peptide CRF1 receptor antagonist NBI30775 (R121919) and Verucerfont are both significantly different from vehicle, CP-316 311, and pexacerfont (PPost hoc analysis shows that both NBI30775 and Verucerfont inhibit ACTH release throughout the following 6 h of measurement (P<0.001 vs vehicle at each time-point, and vs the respective pretreatment baseline)[1].
References:
[1]. Schwandt ML, et al. The CRF1 Antagonist Verucerfont in Anxious Alcohol-Dependent Women: Translation of Neuroendocrine, But not of Anti-Craving Effects. Neuropsychopharmacology. 2016 Nov;41(12):2818-2829.
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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