PSEM 89S |
Catalog No.GC50449 |
Le PSEM 89S est un agoniste sélectif et pénétrant dans le cerveau pour les canaux ioniques résultants.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1336913-03-1
Sample solution is provided at 25 µL, 10mM.
PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist (EC50 values are 3.4 and 2.2 μM, respectively). Activates cortical neurons expressing PSAML141F,Y115F-5-HT3 chimeric ion channels and inhibits activity of neurons expressing PSAML141F-GlyR in vitro. Silences hypothalamic AGRP neurons transfected with PSAML141F-GlyR chimeric ion channels in mice in vivo, leading to suppression of feeding. Brain penetrant. Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene.
Magnus et al (2011) Chemical and genetic engineering of selective ion channel-ligand interactions. Science 333 1292 PMID:21885782 |Cerritelli et al (2016) Activation of brainstem pro-opiomelanocortin neurons produces opioidergic analgesia, bradycardia and bradypnoea. PLoS One 11 e0153187 PMID:27077912
Average Rating: 5
(Based on Reviews and 2 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *