GLPBio

Ganoderic acid Y

Catalog No.: GC62984Purity:>98.00%
COASDSData Sheet
Ganoderic acid Y is HMG-CoA Reductase inhibitor and α-glucosidase inhibitor with IC50s of 8.6μM and 170μM, respectively.

Products are for research use only. Not for human use. We do not sell to patients.

Ganoderic acid Y
Cas No.: 86377-52-8
1mgIn Stock
$450.00
1
5mgIn Stock
$1,350.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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Description

Ganoderic acid Y is HMG-CoA Reductase inhibitor and α-glucosidase inhibitor with IC50s of 8.6μM and 170μM, respectively [1,2]. Ganoderic acid Y can be used in cancer research.

In vitro，Ganoderic acid Y inhibited enterovirus 71 (EV71) replication through blocking EV71 uncoating[3]. Ganoderic acid Y inhibited the cell viabilities of K562 and PC-3 cell lines with IC50s of 17.5 and 179.8μM [2]. Ganoderic acid Y inhibited cell viability of H460 in concentration-dependent manner, with IC₅₀ of 22.4μM [4].

References:
[1]. Chen, Xian-Qiang, et al. "Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against α-glucosidase." Phytochemistry 149 (2018): 103-115.
[2]. Wang, Kai, et al. "Lanostane triterpenes from the Tibetan medicinal mushroom Ganoderma leucocontextum and their inhibitory effects on HMG-CoA reductase and α-glucosidase." Journal of Natural Products 78.8 (2015): 1977-1989.
[3]. Zhang, Wenjing, et al. "Antiviral effects of two Ganoderma lucidum triterpenoids against enterovirus 71 infection." Biochemical and biophysical research communications 449.3 (2014): 307-312.
[4]. Du, Guo-Hua, et al. "Anti-tumor target prediction and activity verification of Ganoderma lucidum triterpenoids." China Journal of Chinese Materia Medica 42.3 (2017): 517-522.

Protocol

Cell experiment [1]:

Cell lines

Lung cancer cell line H460

Preparation Method

The cell suspension of tumor cells was inoculated at a certain concentration into a 96-well culture plate and incubated in a 37℃, 5% CO2 incubator for 24 hours. The working solution of Ganoderic acid Y was added at a final concentration of 0.1, 1, 10, 100μM (4 duplicate wells for each concentration). After 72 hours of treatment, the culture medium was discarded, detect cell viability using the MTT method.

Reaction Conditions

0.1, 1, 10, 100μM; 72 hours

Applications

Ganoderic acid Y inhibited cell viability of H460, with IC₅₀ of 22.4μM.

References:
[1]. Du, Guo-Hua, et al. "Anti-tumor target prediction and activity verification of Ganoderma lucidum triterpenoids." China Journal of Chinese Materia Medica 42.3 (2017): 517-522.

Product Documents

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
86377-52-8
Molecular Formula
C30H46O3
Molecular Weight
454.68
Storage
Store at -20°C, protect from light
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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