ACX-362E (Synonyms: ACX-362E; GLS-362E) |
| Catalog No.GC35247 |
ACX-362E (ACX-362E) is a first-in-class, orally active DNA polymerase IIIC (pol IIIC) inhibitor, with a Ki of 0.325 μM for the DNA pol IIIC from C.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1275582-97-2
Sample solution is provided at 25 µL, 10mM.
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ACX-362E is an orally available DNA polymerase IIIC (pol IIIC) inhibitor, acts as an antimicrobial agent to treat Gram-positive infections, with a MIC50 of 2 μg/mL for C. difficile. ACX-362E displays very potent in vitro and in vivo activities against broad spectrum of C. difficile pathogens[1]. MIC50: 2 μg/mL (C. difficile)[1]
[1]. Xu WC, et al. Discovery and development of DNA polymerase IIIC inhibitors to treat Gram-positive infections. Bioorg Med Chem. 2019 Jun 11. pii: S0968-0896(19)30663-7.
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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