GLPBio

ACX-362E

Catalog No.: GC35247Purity:>99.50%Synonyms: ACX-362E; GLS-362E
COASDSData Sheet
ACX-362E (ACX-362E) is a first-in-class, orally active DNA polymerase IIIC (pol IIIC) inhibitor, with a Ki of 0.325 μM for the DNA pol IIIC from C.

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ACX-362E
Cas No.: 1275582-97-2
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Citations

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    641, 529–536 (2025)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    35, 97–116 (2025)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

ACX-362E is an orally available DNA polymerase IIIC (pol IIIC) inhibitor, acts as an antimicrobial agent to treat Gram-positive infections, with a MIC50 of 2 μg/mL for C. difficile. ACX-362E displays very potent in vitro and in vivo activities against broad spectrum of C. difficile pathogens[1]. MIC50: 2 μg/mL (C. difficile)[1]

[1]. Xu WC, et al. Discovery and development of DNA polymerase IIIC inhibitors to treat Gram-positive infections. Bioorg Med Chem. 2019 Jun 11. pii: S0968-0896(19)30663-7.

Product Documents

Purity:>99.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
1275582-97-2
Synonyms
ACX-362E; GLS-362E
SMILES
O=C1NC(NCC2=CC=C(Cl)C(Cl)=C2)=NC3=C1N(CCN4CCOCC4)C=N3
Molecular Formula
C18H20Cl2N6O2
Molecular Weight
423.3
Solubility
DMSO : 62.5 mg/mL (147.65 mM; Need ultrasonic)
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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