Duocarmycin |
| Catalog No.GC35907 |
Duocarmycin, a DNA minor-groove alkylator, is an antibody drug conjugates (ADCs) toxin. Duocarmycin is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity.
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Cas No.: 1116745-06-2
Sample solution is provided at 25 µL, 10mM.
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Duocarmycin is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity. Duocarmycin is a DNA minor groove binding alkylating agent and explored as drug-antibody conjugates (ADCs) [1].
[1]. Koch MF, et al. Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues. Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13550-4.
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