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Home >> Signaling Pathways >> DNA Damage/DNA Repair >> DNA Alkylator/Crosslinker

DNA Alkylator/Crosslinker

DNA alkylator/crosslinker is a molecule that alkylates DNA or can cross link with DNA. DNA alkylator/crosslinker can have mutagenic, pharmaceutical, or other effects. Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene. Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor. Alkylation with only one carbon is termed methylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents. Crosslinking of DNA occurs when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink). Crosslinks also occur between DNA and protein. DNA replication is blocked by crosslinks, which causes replication arrest and cell death if the crosslink is not repaired. The RAD51 family plays a role in repair.

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Products for  DNA Alkylator/Crosslinker

  1. Cat.No. Product Name Information
  2. GC34955 (+)-CBI-CDPI1 (+)-CBI-CDPI1 is an enhanced functional analog of CC-1065. (+)-CBI-CDPI1 is a DNA alkylating agent. (+)-CBI-CDPI1 is an antibody drug conjugates (ADCs) toxin. (+)-CBI-CDPI1 Chemical Structure
  3. GC34956 (+)-CBI-CDPI2 (+)-CBI-CDPI2 is an enhanced functional analog of CC-1065. (+)-CBI-CDPI1 is a DNA alkylating agent. (+)-CBI-CDPI2 is an antibody drug conjugates (ADCs) toxin. (+)-CBI-CDPI2 Chemical Structure
  4. GC60421 (S)-Seco-Duocarmycin SA (S)-Seco-Duocarmycin SA is a DNA alkylator, cytotoxic to cancer cells, and acts as a ADC cytotoxin for antibody-drug conjugates. (S)-Seco-Duocarmycin SA Chemical Structure
  5. GC49470 1-Ethyl-1-nitrosourea (hydrate)

    ENU, Ethylnitrosourea, N-Ethyl-N-nitrosourea, N-Nitroso-N-ethylurea

     A DNA alkylating agent 1-Ethyl-1-nitrosourea (hydrate) Chemical Structure
  6. GC71560 2-Iodoacetamide-d4 2-Iodoacetamide-d4 is the deuterium labeled 2-Iodoacetamide. 2-Iodoacetamide-d4 Chemical Structure
  7. GC52129 3-Amino-5-hydroxybenzoic Acid

    AHBA

     3-Amino-5-hydroxybenzoic Acid Chemical Structure
  8. GC42401 4-hydroperoxy Cyclophosphamide

    4-OOH-CY

     4-hydroperoxy Cyclophosphamide, the active metabolite of cyclophosphamide, can cross-link DNA and induce T cell apoptosis independently of caspase receptor activation. It also activates the mitochondrial death pathway through the production of reactive oxygen species (ROS). 4-hydroperoxy Cyclophosphamide Chemical Structure
  9. GC68332 4-Hydroperoxy Cyclophosphamide-d4 4-Hydroperoxy Cyclophosphamide-d4 Chemical Structure
  10. GC90549 5-Aminoimidazole-4-carboxamide (hydrate)

    A synthetic precursor

     5-Aminoimidazole-4-carboxamide (hydrate) Chemical Structure
  11. GC14564 Altretamine

    2,4,6-Tris(dimethylamino)-1,3,5-triazine, Hexamethylmelamine, HMM, NSC 13875

     Antineoplastic agent Altretamine Chemical Structure
  12. GC35310 Altretamine hydrochloride

    ENT-50852 hydrochloride; RB-1515 hydrochloride; WR-95704 hydrochloride

     Altretamine hydrochloride is an alkylating antineoplastic agent. Altretamine hydrochloride Chemical Structure
  13. GC64354 Bendamustine Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties. Bendamustine Chemical Structure
  14. GC34305 Bendamustine D4 (SDX-105 D4) Bendamustine D4 (SDX-105 D4) Chemical Structure
  15. GC10744 Bendamustine HCl

    SDX-105

     Bendamustine HCl (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine HCl activats DNA-damage stress response and apoptosis. Bendamustine HCl has potent alkylating, anticancer and antimetabolite properties. Bendamustine HCl Chemical Structure
  16. GC46914 Bendamustine-d4 (hydrochloride) A neuropeptide with diverse biological activities Bendamustine-d4 (hydrochloride) Chemical Structure
  17. GC13671 Busulfan

    Busulphan, Mielosan, Milecitan, Myeloleukon, Mylecytan, Myleran, NCI C01592, NSC 750

     DNA alkylating agent Busulfan Chemical Structure
  18. GC46962 Busulfan-d8

    Busulphan-d8, Mielosan-d8, Milecitan-d8, Myeloleukon-d8, Mylecytan-d8, Myleran-d8

     An internal standard for the quantification of busulfan Busulfan-d8 Chemical Structure
  19. GC19086 Calicheamicin Calicheamicin is a cytotoxic agent that causes double-strand DNA breaks. Calicheamicin Chemical Structure
  20. GC11207 Carboplatin

    CBDCA, CDDCA, cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II), NSC 201345, NSC 241240

     Carboplatin (NSC 241240) is a non-specific DNA cross-linking agent that inhibits DNA synthesis and transcription. Its main target is DNA rather than specific proteins . Carboplatin Chemical Structure
  21. GC15793 Carmustine

    BCNU, bis-Chloroethylnitrosourea, NSC 409962

     cell-cycle phase nonspecific alkylating antineoplastic agent Carmustine Chemical Structure
  22. GC43209 CB-1954

    NSC 115829, Tretazicar

     CB-1954 (CB 1954), an antitumor prodrug, is highly selective against the Walker 256 rat tumour line. CB-1954 is enzymatically activated to generate a bifunctional agent, which can form DNA-DNA interstrand cross-links. CB-1954 in rat cells involves the reduction of its 4-nitro group to a 4-hydroxylamine by the enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1). CB-1954 Chemical Structure
  23. GC12908 Chlorambucil

    CB-1348, NCI 3088, NSC 3088

    nitrogen mustard alkylating agent

     Chlorambucil Chemical Structure
  24. GC47078 Chlorambucil-d8

    CB-1348-d8; WR-139013-d8

     A neuropeptide with diverse biological activities Chlorambucil-d8 Chemical Structure
  25. GC91297 Cholesterol-Doxorubicin

    A prodrug form of doxorubicin

     Cholesterol-Doxorubicin Chemical Structure
  26. GC11908 Cisplatin

    CDDP

     Cisplatin is one of the best and first metal-based chemotherapeutic drugs, which is used for wide range of solid cancers such as testicular, ovarian, bladder, lung, cervical, head and neck cancer, gastric cancer and some other cancers. Cisplatin Chemical Structure
  27. GC90657 COMC

    An anticancer agent

     COMC Chemical Structure
  28. GC11145 Cyclophosphamide Cyclophosphamide is a frequently used chemotherapy, often in combination with other chemotherapy types, for the treatment of breast cancer, malignant lymphomas, multiple myeloma, and neuroblastom. Cyclophosphamide Chemical Structure
  29. GC14077 Cyclophosphamide monohydrate An alkylating agent Cyclophosphamide monohydrate Chemical Structure
  30. GC35907 Duocarmycin Duocarmycin, a DNA minor-groove alkylator, is an antibody drug conjugates (ADCs) toxin. Duocarmycin is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity. Duocarmycin Chemical Structure
  31. GC38080 Duocarmycin Analog Duocarmycin Analog is an analog of Duocarmycin, and used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog Chemical Structure
  32. GC35909 Duocarmycin GA Duocarmycin GA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin GA can be used against multi-drug resistant cell lines. Duocarmycin GA Chemical Structure
  33. GC35910 Duocarmycin MA Duocarmycin MA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MA can be used against multi-drug resistant cell lines. Duocarmycin MA Chemical Structure
  34. GC35911 Duocarmycin MB Duocarmycin MB is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MB can be used against multi-drug resistant cell lines. Duocarmycin MB Chemical Structure
  35. GC32187 Duocarmycin TM

    CBI-TMI

     Duocarmycin TM (CBI-TMI) is a potent antitumor antibiotic. Duocarmycin TM induces a sequence-selective alkylation of duplex DNA. Duocarmycin TM Chemical Structure
  36. GC16003 Ifosfamide

    Isophosphamide, NSC 109724

     Cytostatic agent Ifosfamide Chemical Structure
  37. GC41340 Illudin M

    DR-15977, (-)-Illudin M, NSC 400978, NSC 626370

     Illudin M is a cytotoxic sesquiterpene from the fungus O. Illudin M Chemical Structure
  38. GC41384 K-TMZ K-TMZ is a DNA alkylating agent. K-TMZ Chemical Structure
  39. GC17865 Lomustine

    CCNU, NCI C04740, NSC 79037

     Antineoplastic drug Lomustine Chemical Structure
  40. GC63050 Lurbinectedin D3

    PM01183-d3

     Lurbinectedin D3 Chemical Structure
  41. GC12393 Melphalan

    Alanine Nitrogen Mustard, Alkeran, NSC 8806, NSC 241286, L-Phenylalanine Mustard

    DNA alkylating agent

     Melphalan Chemical Structure
  42. GC36598 Methylnitronitrosoguanidine(wetted with ca. 50% Water)

    Methylnitronitrosoguanidine (MNNG) is an orally active alkylating agent, shows toxic and mutagenic effects.

     Methylnitronitrosoguanidine(wetted with ca. 50% Water) Chemical Structure
  43. GC32886 Miriplatin (SM-11355) Miriplatin (SM-11355) (SM-11355) is a chemotherapy agent which belongs to the class of alkylating agents. Miriplatin (SM-11355) Chemical Structure
  44. GC36615 Miriplatin hydrate Miriplatin hydrate (SM-11355 hydrate) is a chemotherapy agent which belongs to the class of alkylating agents. Miriplatin hydrate Chemical Structure
  45. GC44243 Monohydroxy Melphalan (hydrochloride)

    Hydroxymelphalan

     Monohydroxy melphalan is a DNA alkylating agent and a degradation product of melphalan. Monohydroxy Melphalan (hydrochloride) Chemical Structure
  46. GC44251 MTIC

    NSC 407347

    MTIC is a DNA alkylating agent, an active metabolite of dacarbazine, and an active degradation product of temozolomide.

     MTIC Chemical Structure
  47. GC39498 N-Nitroso-N-methylurea N-Nitroso-N-methylurea (NMU; MNU; NMH) is a potent carcinogen, mutagen and teratogen. N-Nitroso-N-methylurea Chemical Structure
  48. GC62501 OBI-3424

    TH-3424

     OBI-3424 (TH-3424) is a prodrug that is selectively converted by AKR1C3 (aldo-keto reductase 1C3) to a potent DNA-alkylating agent. OBI-3424 can be used for hepatocellular carcinoma, castrate-resistant prostate cancer, and acute lymphoblastic leukemia (ALL) research. OBI-3424 Chemical Structure
  49. GC17716 Oxaliplatin

    Lipoxal, NSC 266046, RP 54780

    Oxaliplatin is a cytotoxic chemotherapy drug used to treat cancer.

     Oxaliplatin Chemical Structure
  50. GC14762 Palifosfamide

    Isophosphoramide Mustard, NSC 297900

     An active metabolite of ifosfamide Palifosfamide Chemical Structure
  51. GC61182 Phosphoramide mustard (cyclohexanamine)

    NSC 69945, PMC

     An alkylating agent and active metabolite of cyclophosphamide Phosphoramide mustard (cyclohexanamine) Chemical Structure
  52. GC61188 PIP-199 PIP-199 is a selective inhibitor of RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC50 of 36 μM. PIP-199 can be used for the research of sensitizing resistant tumors to DNA crosslinking chemotherapeutics. PIP-199 Chemical Structure
  53. GC32946 PK11007 PK11007 is a mild thiol alkylator with anticancer activity. PK11007 stabilizes p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. PK11007 induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels. PK11007 Chemical Structure
  54. GC63154 PR-104 PR-104 is a selective hypoxia-activated DNA cross-linking agent and can be used for the research of multiple tumor xenograft models. PR-104, as a nitrogen mustard pre-prodrug, is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A. PR-104 Chemical Structure
  55. GC62490 PR-104A

    SN 27858

     PR-104A (SN 27858) is the alcohol metabolite of phosphate prodrug PR-104. PR-104A is a hypoxia-selective DNA cross-linking agent/DNA-damaging agent and cytotoxin. Antitumor Activity. PR-104A is metabolized under hypoxia by the 1-electron NADPH:cytochrome P450 oxidoreductase. PR-104A can be used for the research of relapsed/refractory T-lineage acute lymphoblastic leukemia (T-ALL). PR-104A Chemical Structure
  56. GC11793 Procarbazine HCl

    Indicarb, Natulan, NSC 77213

     Procarbazine HCl is an orally active alkylating agent, with anticancer activity. Procarbazine HCl can be used in Hodgkin's disease research. Procarbazine HCl Chemical Structure
  57. GC12793 RITA (NSC 652287)

    2,5bis(5hydroxymethyl2thienyl) Furan, NSC 652287, Reactivation of p53 and Induction of Tumor Cell Apoptosis

     An inhibitor of the p53-HDM-2 interaction RITA (NSC 652287) Chemical Structure
  58. GC37593 Satraplatin

    BMS-182751, BMY 45594, JM 216

     Satraplatin is an alkylating agent, with potent antitumor effect. Satraplatin Chemical Structure
  59. GC38349 Seco-Duocarmycin SA Seco-Duocarmycin SA is a DNA alkylator, and is used as an ADC cytotoxin. Seco-Duocarmycin SA Chemical Structure
  60. GC38354 Seco-Duocarmycin TM Seco-Duocarmycin TM is a DNA alkylator agent belonging to Duocarmycins family that inhibits DNA synthesis. Seco-Duocarmycin TM is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates (ADC). Seco-Duocarmycin TM Chemical Structure
  61. GC37625 Semustine Semustine is a DNA alkylator, binds to DNA, and acts as a cancer chemotherapeutic agent. Semustine Chemical Structure
  62. GC69882 SG2057

    DRG16

    SG2057 (DRG16) is a PBD dimer containing a pentadiene bond, which selectively binds to sequences in the minor groove of DNA, forming inter- and intra-strand crosslink adducts. SG2057 is an effective anti-tumor agent.

     SG2057 Chemical Structure
  63. GC62691 SG3199 SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249). SG3199 Chemical Structure
  64. GC34086 SJG-136 (NSC-694501)

    NSC-694501

     SJG-136 (NSC-694501) is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA. SJG-136 (NSC-694501) has potent antitumor activity. SJG-136 (NSC-694501) Chemical Structure
  65. GC17131 Streptozocin

    Estreptozocin, NSC 37917, NSC 85998, Streptozocin, STZ, U 9889

     Streptozocin, a potent DNA-methylating antibiotic, is a naturally occurring nitrosoamide used for extensively to produce diabetes in experimental models. Streptozocin Chemical Structure
  66. GC13667 Temozolomide

    CCRG 81045, MB 39831, Methazolastone, NSC 362856, Temodal, TMZ

     Temozolomide is an oral activity alkylating agent that induces the formation of O6-methylguanine in DNA, which mispairs with thymine during the following cycle of DNA replication, leading to activation of the apoptotic pathways, Temozolomide could crosses the blood-brain barrier and is indicated for malignant gliomas and metastatic melanomas. Temozolomide Chemical Structure
  67. GC52076 Temozolomide Acid

    Temozolomide 8-Carboxylic Acid, TMZA

     Temozolomide Acid is a carboxylic acid derivative of Temozolomide. Temozolomide is a DNA alkylating agent, methylating the guanine and adenine bases of DNA, causing breaks in DNA double strand, cell cycle arrest, and eventually cell death. Temozolomide Acid has an activity similar to the parent compound Temozolomide with the same anticancer activity. Temozolomide Acid Chemical Structure
  68. GC74145 Tesirine intermediate-1 Tesirine intermediate-1 is the intermediate of Tesirine. Tesirine intermediate-1 Chemical Structure
  69. GC74107 Tesirine intermediate-2 Tesirine intermediate-2 is the intermediate of Tesirine. Tesirine intermediate-2 Chemical Structure
  70. GC16158 Thio-TEPA

    NCI C01649, NSC 6396, Triethylenethiophosphoramide

     alkylating agent used to treat cancer Thio-TEPA Chemical Structure
  71. GC32918 Treosulfan (NSC 39069) Treosulfan (NSC 39069) (NSC 39069) is a bifunctional alkylating agent with activity in ovarian cancer and other solid tumor types. Treosulfan (NSC 39069) Chemical Structure
  72. GC37860 Uramustine Uramustine Chemical Structure
  73. GC10339 VAL-083 VAL-083 Chemical Structure

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