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DNA Alkylator/Crosslinker

DNA alkylator/crosslinker is a molecule that alkylates DNA or can cross link with DNA. DNA alkylator/crosslinker can have mutagenic, pharmaceutical, or other effects. Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene. Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor. Alkylation with only one carbon is termed methylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents. Crosslinking of DNA occurs when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink). Crosslinks also occur between DNA and protein. DNA replication is blocked by crosslinks, which causes replication arrest and cell death if the crosslink is not repaired. The RAD51 family plays a role in repair.

Targets for  DNA Alkylator/Crosslinker

Products for  DNA Alkylator/Crosslinker

  1. Cat.No. Product Name Information
  2. GC60421 (S)-Seco-Duocarmycin SA (S)-Seco-Duocarmycin SA  Chemical Structure
  3. GC49470 1-Ethyl-1-nitrosourea (hydrate) A DNA alkylating agent 1-Ethyl-1-nitrosourea (hydrate)  Chemical Structure
  4. GC14564 Altretamine Antineoplastic agent Altretamine  Chemical Structure
  5. GC35310 Altretamine hydrochloride Altretamine hydrochloride  Chemical Structure
  6. GC64354 Bendamustine Bendamustine  Chemical Structure
  7. GC34305 Bendamustine D4 (SDX-105 D4) Bendamustine D4 (SDX-105 D4)  Chemical Structure
  8. GC10744 Bendamustine HCl Cytostatic agent for non-Hodgkin lymphomas Bendamustine HCl  Chemical Structure
  9. GC13671 Busulfan DNA alkylating agent Busulfan  Chemical Structure
  10. GC19086 Calicheamicin Calicheamicin is a cytotoxic agent that causes double-strand DNA breaks. Calicheamicin  Chemical Structure
  11. GC11207 Carboplatin Antitumor agent that forms platinum-DNA adducts. Carboplatin  Chemical Structure
  12. GC15793 Carmustine cell-cycle phase nonspecific alkylating antineoplastic agent Carmustine  Chemical Structure
  13. GC43209 CB-1954 CB-1954 is a prodrug that is enzymatically activated to generate an antitumor agent that forms DNA-DNA interstrand crosslinks. CB-1954  Chemical Structure
  14. GC12908 Chlorambucil

    nitrogen mustard alkylating agent

    Chlorambucil  Chemical Structure
  15. GC11908 Cisplatin

    Inhibits DNA synthesis,chemotherapy drug

    Cisplatin  Chemical Structure
  16. GC11145 Cyclophosphamide Nitrogen mustard alkylating agent and prodrug Cyclophosphamide  Chemical Structure
  17. GC14077 Cyclophosphamide monohydrate

    Alkylating, Cytotoxic agent,Antitumor activity

    Cyclophosphamide monohydrate  Chemical Structure
  18. GC38080 Duocarmycin Analog Duocarmycin Analog  Chemical Structure
  19. GC32187 Duocarmycin TM Duocarmycin TM  Chemical Structure
  20. GC16003 Ifosfamide Cytostatic agent Ifosfamide  Chemical Structure
  21. GC41340 Illudin M Illudin M is a cytotoxic sesquiterpene from the fungus O. Illudin M  Chemical Structure
  22. GC41384 K-TMZ K-TMZ is a DNA alkylating agent. K-TMZ  Chemical Structure
  23. GC17865 Lomustine Antineoplastic drug Lomustine  Chemical Structure
  24. GC63050 Lurbinectedin D3 Lurbinectedin D3  Chemical Structure
  25. GC36598 Methylnitronitrosoguanidine An alkylating agent with toxic and mutagenic effects Methylnitronitrosoguanidine  Chemical Structure
  26. GC32886 Miriplatin (SM-11355) Miriplatin (SM-11355)  Chemical Structure
  27. GC36615 Miriplatin hydrate Miriplatin hydrate  Chemical Structure
  28. GC12353 Mitomycin C

    Inhibit DNA synthesis,antibiotic and antitumor agent

    Mitomycin C  Chemical Structure
  29. GC44243 Monohydroxy Melphalan (hydrochloride) Monohydroxy melphalan is a DNA alkylating agent and a degradation product of melphalan. Monohydroxy Melphalan (hydrochloride)  Chemical Structure
  30. GC44251 MTIC

    MTIC is a DNA alkylating agent, an active metabolite of dacarbazine, and an active degradation product of temozolomide.

    MTIC  Chemical Structure
  31. GC39498 N-Nitroso-N-methylurea N-Nitroso-N-methylurea  Chemical Structure
  32. GC62501 OBI-3424 OBI-3424  Chemical Structure
  33. GC17716 Oxaliplatin Antitumor agent Oxaliplatin  Chemical Structure
  34. GC14762 Palifosfamide Active metabolite of ifosfamide (IFOS) Palifosfamide  Chemical Structure
  35. GC61182 Phosphoramide mustard (cyclohexanamine) Phosphoramide mustard (cyclohexanamine)  Chemical Structure
  36. GC61188 PIP-199 PIP-199  Chemical Structure
  37. GC32946 PK11007 PK11007  Chemical Structure
  38. GC63154 PR-104 PR-104  Chemical Structure
  39. GC62490 PR-104A PR-104A  Chemical Structure
  40. GC11793 Procarbazine HCl Antineoplastic chemotherapy drug Procarbazine HCl  Chemical Structure
  41. GC12793 RITA (NSC 652287) Mdm2-p53 interaction and p53 ubiquitination blocking RITA (NSC 652287)  Chemical Structure
  42. GC37593 Satraplatin Satraplatin  Chemical Structure
  43. GC38349 Seco-Duocarmycin SA Seco-Duocarmycin SA  Chemical Structure
  44. GC38354 Seco-Duocarmycin TM Seco-Duocarmycin TM  Chemical Structure
  45. GC37625 Semustine Semustine  Chemical Structure
  46. GC62691 SG3199 SG3199  Chemical Structure
  47. GC34086 SJG-136 (NSC-694501) SJG-136 (NSC-694501)  Chemical Structure
  48. GC17131 Streptozocin Antibiotic and antitumor agent Streptozocin  Chemical Structure
  49. GC13667 Temozolomide An oral DNA alkylating agent used to treat some brain cancers Temozolomide  Chemical Structure
  50. GC16158 Thio-TEPA alkylating agent used to treat cancer Thio-TEPA  Chemical Structure
  51. GC32918 Treosulfan (NSC 39069) Treosulfan (NSC 39069)  Chemical Structure
  52. GC10339 VAL-083

    Bi-functional alkylating agent

    VAL-083  Chemical Structure

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