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Home >> Signaling Pathways >> DNA Damage/DNA Repair >> DNA Alkylator/Crosslinker

DNA Alkylator/Crosslinker

DNA alkylator/crosslinker is a molecule that alkylates DNA or can cross link with DNA. DNA alkylator/crosslinker can have mutagenic, pharmaceutical, or other effects. Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene. Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor. Alkylation with only one carbon is termed methylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents. Crosslinking of DNA occurs when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink). Crosslinks also occur between DNA and protein. DNA replication is blocked by crosslinks, which causes replication arrest and cell death if the crosslink is not repaired. The RAD51 family plays a role in repair.

Targets for  DNA Alkylator/Crosslinker

Products for  DNA Alkylator/Crosslinker

  1. Cat.No. Product Name Information
  2. GC60421 (S)-Seco-Duocarmycin SA (S)-Seco-Duocarmycin SA Chemical Structure
  3. GC49470 1-Ethyl-1-nitrosourea (hydrate) A DNA alkylating agent 1-Ethyl-1-nitrosourea (hydrate) Chemical Structure
  4. GC14564 Altretamine Antineoplastic agent Altretamine Chemical Structure
  5. GC35310 Altretamine hydrochloride Altretamine hydrochloride Chemical Structure
  6. GC64354 Bendamustine Bendamustine Chemical Structure
  7. GC34305 Bendamustine D4 (SDX-105 D4) Bendamustine D4 (SDX-105 D4) Chemical Structure
  8. GC10744 Bendamustine HCl Cytostatic agent for non-Hodgkin lymphomas Bendamustine HCl Chemical Structure
  9. GC13671 Busulfan DNA alkylating agent Busulfan Chemical Structure
  10. GC19086 Calicheamicin Calicheamicin is a cytotoxic agent that causes double-strand DNA breaks. Calicheamicin Chemical Structure
  11. GC11207 Carboplatin Antitumor agent that forms platinum-DNA adducts. Carboplatin Chemical Structure
  12. GC15793 Carmustine cell-cycle phase nonspecific alkylating antineoplastic agent Carmustine Chemical Structure
  13. GC43209 CB-1954 CB-1954 is a prodrug that is enzymatically activated to generate an antitumor agent that forms DNA-DNA interstrand crosslinks. CB-1954 Chemical Structure
  14. GC12908 Chlorambucil

    nitrogen mustard alkylating agent

     Chlorambucil Chemical Structure
  15. GC11908 Cisplatin

    Inhibits DNA synthesis,chemotherapy drug

     Cisplatin Chemical Structure
  16. GC11145 Cyclophosphamide Nitrogen mustard alkylating agent and prodrug Cyclophosphamide Chemical Structure
  17. GC14077 Cyclophosphamide monohydrate

    Alkylating, Cytotoxic agent,Antitumor activity

     Cyclophosphamide monohydrate Chemical Structure
  18. GC38080 Duocarmycin Analog Duocarmycin Analog Chemical Structure
  19. GC32187 Duocarmycin TM Duocarmycin TM Chemical Structure
  20. GC16003 Ifosfamide Cytostatic agent Ifosfamide Chemical Structure
  21. GC41340 Illudin M Illudin M is a cytotoxic sesquiterpene from the fungus O. Illudin M Chemical Structure
  22. GC41384 K-TMZ K-TMZ is a DNA alkylating agent. K-TMZ Chemical Structure
  23. GC17865 Lomustine Antineoplastic drug Lomustine Chemical Structure
  24. GC63050 Lurbinectedin D3 Lurbinectedin D3 Chemical Structure
  25. GC36598 Methylnitronitrosoguanidine An alkylating agent with toxic and mutagenic effects Methylnitronitrosoguanidine Chemical Structure
  26. GC32886 Miriplatin (SM-11355) Miriplatin (SM-11355) Chemical Structure
  27. GC36615 Miriplatin hydrate Miriplatin hydrate Chemical Structure
  28. GC12353 Mitomycin C

    Inhibit DNA synthesis,antibiotic and antitumor agent

     Mitomycin C Chemical Structure
  29. GC44243 Monohydroxy Melphalan (hydrochloride) Monohydroxy melphalan is a DNA alkylating agent and a degradation product of melphalan. Monohydroxy Melphalan (hydrochloride) Chemical Structure
  30. GC44251 MTIC

    MTIC is a DNA alkylating agent, an active metabolite of dacarbazine, and an active degradation product of temozolomide.

     MTIC Chemical Structure
  31. GC39498 N-Nitroso-N-methylurea N-Nitroso-N-methylurea Chemical Structure
  32. GC62501 OBI-3424 OBI-3424 Chemical Structure
  33. GC17716 Oxaliplatin Antitumor agent Oxaliplatin Chemical Structure
  34. GC14762 Palifosfamide Active metabolite of ifosfamide (IFOS) Palifosfamide Chemical Structure
  35. GC61182 Phosphoramide mustard (cyclohexanamine) Phosphoramide mustard (cyclohexanamine) Chemical Structure
  36. GC61188 PIP-199 PIP-199 Chemical Structure
  37. GC32946 PK11007 PK11007 Chemical Structure
  38. GC63154 PR-104 PR-104 Chemical Structure
  39. GC62490 PR-104A PR-104A Chemical Structure
  40. GC11793 Procarbazine HCl Antineoplastic chemotherapy drug Procarbazine HCl Chemical Structure
  41. GC12793 RITA (NSC 652287) Mdm2-p53 interaction and p53 ubiquitination blocking RITA (NSC 652287) Chemical Structure
  42. GC37593 Satraplatin Satraplatin Chemical Structure
  43. GC38349 Seco-Duocarmycin SA Seco-Duocarmycin SA Chemical Structure
  44. GC38354 Seco-Duocarmycin TM Seco-Duocarmycin TM Chemical Structure
  45. GC37625 Semustine Semustine Chemical Structure
  46. GC62691 SG3199 SG3199 Chemical Structure
  47. GC34086 SJG-136 (NSC-694501) SJG-136 (NSC-694501) Chemical Structure
  48. GC17131 Streptozocin Antibiotic and antitumor agent Streptozocin Chemical Structure
  49. GC13667 Temozolomide An oral DNA alkylating agent used to treat some brain cancers Temozolomide Chemical Structure
  50. GC16158 Thio-TEPA alkylating agent used to treat cancer Thio-TEPA Chemical Structure
  51. GC32918 Treosulfan (NSC 39069) Treosulfan (NSC 39069) Chemical Structure
  52. GC10339 VAL-083

    Bi-functional alkylating agent

     VAL-083 Chemical Structure

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