FD-IN-1 |
| Catalog No.GC36035 |
FD-IN-1 (Compound 12) is an orally bioavailable and selective factor D (FD) inhibitor with an IC50 of 12 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1646682-14-5
Sample solution is provided at 25 µL, 10mM.
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FD-IN-1 (Compound 12) is a factor D (FD) inhibitor with an IC50 of 12 nM. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system. FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC50s of 7.7 and 6.5µM, respectively[1].
[1]. Karki RG, et al. Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway. J Med Chem. 2019 May 9;62(9):4656-4668.
Average Rating: 5 (Based on Reviews and 14 reference(s) in Google Scholar.)
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