IDO/TDO-IN-1 |
| Catalog No.GC36294 |
IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively .
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2033173-01-0
Sample solution is provided at 25 µL, 10mM.
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IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively [1]. IC50: 9.7 nM (Indoleamine-2,3-dioxygenase), 47 nM (Tryptophan 2,3-dioxygenase)[1]
IDO/TDO-IN-1 inhibits IDO in the Hela cell line with an IC50 of 76 nM[1].
[1]. Tu W, et al. Discovery of Imidazoisoindole Derivatives as Highly Potent and Orally Active Indoleamine-2,3-dioxygenase Inhibitors. ACS Med Chem Lett. 2019 Jun 3;10(6):949-953.
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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