GLPBio

IDO

Read More about this category

Indoleamine 2,3-dioxygenase (IDO) is an enzyme catalyzing the oxidative degradation of L-tryptophan in the kynurenine pathway, in which the pyrrole ring of L-tryptophan is cleaved to generate N-formyl-kynurenine. Mature human IDO enzyme is a 45 kDa monomeric protein of 403 amino acids that is encoded by the IDO gene (15 kb with 10 exons). According to X-ray crystallographic analysis, the chemical structure of human IDO enzyme consists of two distinct α-helical domains (one small and one large) and a heme prosthetic group, where the heme is coordinated to the active site by a histidine (His) imidazole as the proximal fifth ligand.

Products Related to IDO(46)

  • GC11008 structure
    GC11008Necrostatin-1
    CAS: 4311-88-0
    Purity: >99.00%

    Necrostatin-1 is a novel small molecule inhibitor of necroptosis. Necrostatin-1 inhibits RIP1 kinase activity (EC 50 =182nM) through allosteric binding.

  • GC11066 structure
    GC11066Indoximod (NLG-8189)
    CAS: 110117-83-4
    Purity: >99.00%

    Indoximod (NLG-8189) (1-Methyl-D-tryptophan) is an orally active indoleamine 2,3-dioxygenase (IDO) pathway inhibitor. Indoximod (NLG-8189) acts as a Trp mimetic in regulating mTOR. Indoximod (NLG-8189) is an immunometabolic adjuvant used for the research of cancer.

  • GC13519 structure
    GC13519Navoximod
    CAS: 1402837-78-8
    Purity: >99.00%

    Navoximod (GDC-0919; NLG-?919) is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM.

  • GC13912 structure
    GC13912NLG919
    CAS: 1402836-58-1
    Purity: >99.50%

    An IDO pathway inhibitor

  • GC14425 structure
    GC14425IDO inhibitor 1
    CAS: 1204669-37-3
    Purity: >98%

    Indoleamine-2,3-dioxygenase inhibitor

  • GC15833 structure
    GC15833Norharmane
    CAS: 244-63-3
    Purity: >98.00%

    inhibitor of indoleamine 2,3-dioxygenase

  • GC15846 structure
    GC15846INCB024360 analogue
    CAS: 914471-09-3
    Purity: >98.00%

    A selective IDO1 inhibitor

  • GC15876 structure
    GC15876IDO-IN-1
    CAS: 914638-30-5
    Purity: >98.00%

    indoleamine-2,3-dioxygenase (IDO) inhibitor

  • GC17968 structure
    GC17968INCB-024360
    CAS: 1204669-58-8
    Purity: >99.50%

    INCB-024360, also known as epacadostat, is an oral small molecule selective IDO1 inhibitor (IC 50 = 71.8nM).

  • GC19079 structure
    GC19079BMS-986205
    CAS: 1923833-60-6
    Purity: >99.50%

    BMS-986205 is a selective, irreversible inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), with an IC 50 of 1.1μM in HEK293 cells overexpressing human IDO1.

  • GC32879 structure
    GC32879PF-06840003 (EOS200271)
    CAS: 198474-05-4
    Purity: >98.00%

    PF-06840003 (EOS200271) (EOS200271) is a highly selective orally bioavailable IDO-1 inhibitor with IC50s of 0.41 μM, 0.59 μM, and 1.5 μM for hIDO-1, dIDO-1, and mIDO-1, respectively.

  • GC32899 structure
    GC32899IDO-IN-4
    CAS: 1629125-65-0
    Purity: >99.00%

    IDO-IN-4 (IDO-IN-4) is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor, extracted from patent WO2014150677A1, Compound example 1 enantiomer 1.

  • GC33012 structure
    GC33012IDO-IN-2
    CAS: 1668565-74-9
    Purity: >99.50%

    IDO-IN-2 is a potent IDO inhibitor with an IC50 value of 4.52 nM in HeLa cell.

  • GC33058 structure
    GC33058IDO-IN-3
    CAS: 2070018-30-1
    Purity: >99.50%

    An inhibitor of IDO1

  • GC33191 structure
    GC33191IDO-IN-9
    CAS: 1888378-12-8
    Purity: >98%

    IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell), extracted from patent WO 2016041489 A1, compound 6.

  • GC33287 structure
    GC33287LY-3381916
    CAS: 2166616-75-5
    Purity: >98.00%

    LY-3381916 is a potent, selective and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.

  • GC33671 structure
    GC33671GNF-PF-3777 (8-Nitrotryptanthrin)
    CAS: 77603-42-0
    Purity: >98%

    GNF-PF-3777 (8-Nitrotryptanthrin) (8-Nitrotryptanthrin) is a potent human indoleamine 2,3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with Ki of 0.97 μM.

  • GC33963 structure
    GC33963IDO-IN-12
    CAS: 1888341-29-4
    Purity: >98.00%

    IDO-IN-12 is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO 2017181849 A1.

  • GC34137 structure
    GC34137IDO-IN-5 (NLG-1489)
    CAS: 1402837-79-9
    Purity: >98%

    IDO-IN-5 (NLG-1489) (NLG-1489) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, compound 1489, has an IC50 of 1-10 μM.

  • GC34139 structure
    GC34139IDO-IN-8 (NLG-1487)
    CAS: 1402837-77-7
    Purity: >99.50%

    IDO-IN-8 (NLG-1487) (NLG-1487) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, compound 1487, has an IC50 of 1-10 μM.

  • GC34149 structure
    GC34149IDO-IN-6 (NLG-1486)
    CAS: 1402837-76-6
    Purity: >99.50%

    IDO-IN-6 (NLG-1486) (NLG-1486) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, Compound 1486, has an IC50 of <1 μM.

  • GC34621 structure
    GC34621IACS-8968
    CAS: 2144425-14-7
    Purity: >98.00%

    IACS-8968 (IDO/TDO Inhibitor) is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively.

  • GC34622 structure
    GC34622IACS-8968 R-enantiomer
    CAS: 2239305-67-8
    Purity: >98.00%

    IACS-8968 (R-enantiomer) is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively.

  • GC34623 structure
    GC34623IACS-8968 S-enantiomer
    CAS: 2239305-70-3
    Purity: >98.00%

    IACS-8968 (S-enantiomer) is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively.