Pro-xylane |
Catalog No.GC37018
One-Click Copy Product Info
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Pro-xylane is a bioactive C-glycoside derived from Fagus sylvatica xylose.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 439685-79-7
Sample solution is provided at 25 µL, 10mM.
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Pro-xylane is a bioactive C-glycoside derived from Fagus sylvatica xylose. Pro-xylane stimulates the synthesis of glycosaminoglycans (GAGs) and hyaluronic acid to fill the extracellular matrix and lock in moisture, while strengthening the dermo-epidermal junction by promoting the synthesis of type IV and VII collagens. Pro-xylane can be used in studies related to skin anti-aging and chronic wound healing[1-4].
In vitro, epidermal keratinocytes and dermal fibroblasts were treated with Pro-xylane (1–3mM) for 48 hours. Pro-xylane significantly induced filaggrin expression and promoted α-smooth muscle actin generation, while inhibiting the secretion of the inflammatory factor prostaglandin E2[5]. Pro-xylane (0.3–3mM) was applied to dermal fibroblasts for 72 hours. Pro-xylane significantly stimulated the synthesis of sulfated glycosaminoglycans (GAGs)[6].
References:
[1] Dou Z, Hu PR, Song LL, et al. Extensive gene mining and facile engineering of a novel carbonyl reductase for asymmetric synthesis of anti-aging (S)-Pro-Xylane from d-xylose. Int J Biol Macromol. 2025 May;305(Pt 2):140976. doi: 10.1016/j.ijbiomac.2025.140976.
[2] Zhao Y, Li Y, Shang J, et al. Engineering a Carbonyl Reductase for High-Efficiency Synthesis of Optically Pure (S)-Pro-Xylane: An Alternative Synthetic Route. J Agric Food Chem. 2025 Apr 23;73(16):9759-9768.
[3] Jiang X, Peng S, Chen Y, et al. A Randomized, Investigator-Blinded, Split-Face, Controlled Trial Evaluating the Efficacy and Satisfaction of a Topical Product Containing Blueberry Extract and Pro-Xylane Combined With Micro-Focused Ultrasound for Anti-aging. J Cosmet Dermatol. 2025 Jul;24(7):e70281.
[4] Zang S, Chen J, Chevalier C, et al. Holistic investigation of the anti-wrinkle and repair efficacy of a facial cream enriched with C-xyloside. J Cosmet Dermatol. 2024 Dec;23(12):4017-4028.
[5] Ablon G, Paturi J, Juchaux F, et al. The Application of a Formulation Containing Hydroxypropyl Tetrahydropyrantriol and Niacinamide to Augment Anti-aging Benefits in a Double-blind, Randomized Nonablative Laser Treatment Study. J Clin Aesthet Dermatol. 2025 Dec;18(12):66-72.
[6] Cavezza A, Boulle C, Guéguiniat A, et al. Synthesis of Pro-Xylane: a new biologically active C-glycoside in aqueous media. Bioorg Med Chem Lett. 2009 Feb 1;19(3):845-9.
| Cell experiment [1]: | |
Cell lines | Human dermal fibroblasts (normal human dermal fibroblast, NHDF) |
Preparation Method | Normal human dermal fibroblast (NHDF) monolayers were cultured in control medium with or without Pro-xylane at the indicated concentrations for 72h at 37°C in humid atmosphere of 95% air and 5% CO₂, and labeled with ³⁵S-sulfur during the final 24h. |
Reaction Conditions | 0.3mM-3.0mM; 72h |
Applications | Pro-xylane significantly stimulated the biosynthesis of sulfated glycosaminoglycans (GAGs) by human fibroblasts in a dose-dependent manner, as evidenced by the increased incorporation of ³⁵S-radioactivity into the isolated GAG fraction. |
References: | |
| Cas No. | 439685-79-7 | SDF | |
| Canonical SMILES | CC(O)C[C@H]1[C@@H]([C@H]([C@H](O)CO1)O)O | ||
| Formula | C8H16O5 | M.Wt | 192.21 |
| Solubility | Water: 250 mg/mL (1300.66 mM); DMSO: ≥ 83.33 mg/mL (433.54 mM) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.2026 mL | 26.0132 mL | 52.0264 mL |
| 5 mM | 1.0405 mL | 5.2026 mL | 10.4053 mL |
| 10 mM | 520.3 μL | 2.6013 mL | 5.2026 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A liquid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)