4-oxo Withaferin A (Synonyms: 4-Dehydrowithaferin A) |
| Catalog No.GC45352 |
4-oxo Withaferin A is the analogue of withaferin A. Withaferin A is a withanolide isolated from Withania somnifera. 4-oxo Withaferin A has the potential for the research of multiple myeloma.
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Cas No.: 6850-30-2
Sample solution is provided at 25 µL, 10mM.
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4-oxo Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells and carboplatin-resistant A2780 (A2780/CP70) cells (IC50s = 7.3 and <1 μM, respectively) and is 4.4-fold selective for A2780 cells over non-cancerous ARPE19 cells.
References
1. Perestelo, N.R., Llanos, G.G., Reyes, C.P., et al. Expanding the chemical space of withaferin A by incorporating silicon to improve its clinical potential on human ovarian carcinoma cells. J. Med. Chem. 62(9), 4571-4585 (2019).
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