GLPBio

4-oxo Withaferin A

Catalog No.: GC45352Purity:>98.00%Synonyms: 4-Dehydrowithaferin A
COASDSData Sheet
4-oxo Withaferin A is the analogue of withaferin A. Withaferin A is a withanolide isolated from Withania somnifera. 4-oxo Withaferin A has the potential for the research of multiple myeloma.

Products are for research use only. Not for human use. We do not sell to patients.

4-oxo Withaferin A
Cas No.: 6850-30-2
1mgIn Stock
$134.00
1
10mgIn Stock
$736.00
1
5mgIn Stock
$468.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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    610, 366–372 (2022)
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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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Description

4-oxo Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells and carboplatin-resistant A2780 (A2780/CP70) cells (IC50s = 7.3 and <1 μM, respectively) and is 4.4-fold selective for A2780 cells over non-cancerous ARPE19 cells.

References
1. Perestelo, N.R., Llanos, G.G., Reyes, C.P., et al. Expanding the chemical space of withaferin A by incorporating silicon to improve its clinical potential on human ovarian carcinoma cells. J. Med. Chem. 62(9), 4571-4585 (2019).

Product Documents

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
6850-30-2
Synonyms
4-Dehydrowithaferin A
SMILES
O=C(C=C1)[C@@]2(C)[C@@]([C@H]3C[C@]4([H])[C@]2([H])CC[C@@]5(C)[C@@]4([H])CC[C@]5([H])[C@H](C)[C@@]6([H])CC(C)=C(CO)C(O6)=O)(O3)C1=O
Molecular Formula
C28H36O6
Molecular Weight
468.6
Solubility
DMF: 5mg/mL,DMSO: 5mg/mL,DMSO:PBS (pH 7.2) (1:1): 0.5mg/mL
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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