GIP (mouse)

GIP (Gastric inhibitory polypeptide) (mouse) is a gastrointestinal hormone that is secreted by the intestinal K cells, and also expressed in and secreted from pancreatic islets. GIP (mouse) promotes insulin secretion from pancreatic β cells via the G-protein-coupled GIP receptor ( GIPR ). GIP (mouse) promotes pancreatic β cell proliferation and inhibits apoptosis. GIP (mouse) also exerts direct lipogenic effects on adipose tissue ^{[1] [2] [3]}.

In Vitro, GIP (mouse) promotes β cell proliferation and inhibits apoptosis, thereby expanding pancreatic β cell mass^[2]. GIP (mouse) (0-10-8 M, 3 h) stimulates significant increases in heparin-releasable lipoprotein lipase (LPL) activity in 3T3-L1 adipocytes in a dose-dependent manner^[3].

References:
[1]. Yukihiro Fujita, et al. Glucose-dependent insulinotropic polypeptide is expressed in pancreatic islet alpha-cells and promotes insulin secretion. Gastroenterology. 2010 May;138(5):1966-75.
[2]. Seino Y, et al. GIP and GLP-1, the two incretin hormones: Similarities and differences. J Diabetes Investig. 2010 Apr 22;1(1-2):8-23.
[3]. Kim SJ, et al. Resistin is a key mediator of glucose-dependent insulinotropic polypeptide (GIP) stimulation of lipoprotein lipase (LPL) activity in adipocytes. J Biol Chem. 2007 Nov 23;282(47):34139-47.