GLPBio

H-Ile-Pro-Pro-OH

Catalog No.: GC32611Purity:>98%
COASDSData Sheet
H-Ile-Pro-Pro-OH, a milk-derived peptide, inhibits angiotensin-converting enzyme (ACE) with an IC50 of 5 μM.

Products are for research use only. Not for human use. We do not sell to patients.

H-Ile-Pro-Pro-OH
Cas No.: 26001-32-1
10mgIn Stock
$73.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

1 publicationsPublications from researchers using this product
IF 10

Description

H-Ile-Pro-Pro-OH, a milk-derived peptide[1], inhibits angiotensin-converting enzyme (ACE)[1] with an IC50 of 5 μM[2]. Antihypertensive tripeptides[1].

Vitro: Ile-Pro-Pro (IPP) increases nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs)[1].

Vivo: Ile-Pro-Pro attenuates arterial dysfunction in L-NAME-treated rats[1]Ile-Pro-Pro (IPP) decreases blood pressure in spontaneously hypertensive rats (SHR) [1].Ile-Pro-Pro (IPP) attenuates the development of atherosclerosis in apolipoprotein E-deficient (apoE(-/-)) mice[1].

[1]. Nonaka A, et al. The milk-derived peptides Val-Pro-Pro and Ile-Pro-Pro attenuate arterial dysfunction in L-NAME-treated rats. Hypertens Res. 2014 Aug;37(8):703-7. [2]. Nakamura Y, et al. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci. 1995 Apr;78(4):777-83.

Chemical Properties

CAS No.
26001-32-1
Molecular Formula
C16H27N3O4
Molecular Weight
325.4
Solubility
Soluble in DMSO
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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