HER2

HER2 is a member of the epidermal growth factor. It initiates the EGF downstream cascade by forming a heterodimer with other ligand-bound EGF receptor. It is associated with breast and ovarian cancers.

Products Related to HER2(12)

GC10250 Mubritinib (TAK 165)
CAS: 366017-09-6
Purity: >99.50%
Mubritinib (TAK 165) is a potent, selective inhibitor of HER2/ErbB2 with IC 50 of 6nM.
GC11172 TAK-285
CAS: 871026-44-7
Purity: >98.00%
HER2/EGFR(HER1) inhibitor
GC13091 CP-724714
CAS: 383432-38-0
Purity: >99.00%
HER2 inhibitor,potent and selective
GC13257 AC480 (BMS-599626)
CAS: 714971-09-2
Purity: >98%
AC480 (BMS-599626) (AC480) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC50s of 20 and 30 nM, respectively. AC480 (BMS-599626) displays ~8-fold less potent to HER4 (IC50=190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. AC480 (BMS-599626) inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy.
GC15271 Tyrphostin AG 879
CAS: 148741-30-4
Purity: >99.50%
HER2 inhibitor
GC17473 Pelitinib (EKB-569)
CAS: 257933-82-7
Purity: >98.00%
Pelitinib (EKB-569) (EKB-569;WAY-EKB 569) is an irreversible inhibitor of EGFR with an IC50 of 38.5 nM; also slightly inhibits Src, MEK/ERK and ErbB2 with IC50s of 282, 800, and 1255 nM, respectively.
GC10362 Neratinib (HKI-272)
CAS: 698387-09-6
Purity: >99.50%
Neratinib (HKI-272) (HKI-272) is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC50s of 59 nM and 92 nM, respectively.
GC10606 BMS-599626 Hydrochloride
CAS: 873837-23-1
Purity: >99.50%
GC10707 Afatinib dimaleate
CAS: 850140-73-7
Purity: >99.50%
An inhibitor of EGFR and ErbB2
GC12087 Canertinib dihydrochloride
CAS: 289499-45-2
Purity: >99.00%
A pan-ErbB tyrosine kinase inhibitor
GC16008 CUDC-101
CAS: 1012054-59-9
Purity: >99.00%
A multi-target inhibitor of HDACs, EGFR, and HER2
GC17916 Poziotinib
CAS: 1092364-38-9
Purity: >98%
A irreversible pan-HER inhibitor

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC10250	Mubritinib (TAK 165)	366017-09-6	>99.50%
GC10250	Mubritinib (TAK 165) is a potent, selective inhibitor of HER2/ErbB2 with IC 50 of 6nM.
GC11172	TAK-285	871026-44-7	>98.00%
GC11172	HER2/EGFR(HER1) inhibitor
GC13091	CP-724714	383432-38-0	>99.00%
GC13091	HER2 inhibitor,potent and selective
GC13257	AC480 (BMS-599626)	714971-09-2	>98%
GC13257	AC480 (BMS-599626) (AC480) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC50s of 20 and 30 nM, respectively. AC480 (BMS-599626) displays ~8-fold less potent to HER4 (IC50=190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. AC480 (BMS-599626) inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy.
GC15271	Tyrphostin AG 879	148741-30-4	>99.50%
GC15271	HER2 inhibitor
GC17473	Pelitinib (EKB-569)	257933-82-7	>98.00%
GC17473	Pelitinib (EKB-569) (EKB-569;WAY-EKB 569) is an irreversible inhibitor of EGFR with an IC50 of 38.5 nM; also slightly inhibits Src, MEK/ERK and ErbB2 with IC50s of 282, 800, and 1255 nM, respectively.
GC10362	Neratinib (HKI-272)	698387-09-6	>99.50%
GC10362	Neratinib (HKI-272) (HKI-272) is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC50s of 59 nM and 92 nM, respectively.
GC10606	BMS-599626 Hydrochloride	873837-23-1	>99.50%
GC10707	Afatinib dimaleate	850140-73-7	>99.50%
GC10707	An inhibitor of EGFR and ErbB2
GC12087	Canertinib dihydrochloride	289499-45-2	>99.00%
GC12087	A pan-ErbB tyrosine kinase inhibitor
GC16008	CUDC-101	1012054-59-9	>99.00%
GC16008	A multi-target inhibitor of HDACs, EGFR, and HER2
GC17916	Poziotinib	1092364-38-9	>98%
GC17916	A irreversible pan-HER inhibitor