GLPBio

Hexokinase

Hexokinases phosphorylates glucose to generate glucose-6-phosphate, the initial step in glucose metabolism. HK1 and HK2 are two subtypes of mitochondrial hexokinases whichs are also involved in antiapopotic and cell survival.

Products Related to Hexokinase(6)

  • GC17430 structure
    GC174302-Deoxy-D-glucose
    CAS: 154-17-6
    Purity: >98.00%

    2-Deoxy-D-glucose (2DG), is a glucose analogue, act as competitive glycolytic inhibitor.

  • GC11532 structure
    GC11532Lonidamine
    CAS: 50264-69-2
    Purity: >99.00%

    Lonidamine is an inhibitor of hexokinase, mitochondrial pyruvate carrier (with a Ki of 2.5μM in isolated rat liver mitochondria) and plasma membrane monocarboxylate transporter, and also inhibits mitochondrial complex II.

  • GC15523 structure
    GC155233-Bromopyruvic acid
    CAS: 1113-59-3
    Purity: >97.00%

    3-Bromopyruvic acid is an antitumor agent able to inhibit aerobic glycolysis and oxidative phosphorylation, with IC 50 values of 15 and 35μM for pyruvate dehydrogenase (PDH) and isocitrate dehydrogenase (IDH), respectively.

  • GC27499 structure
    GC27499PROTAC HK2 Degrader-1
    CAS: 3033812-84-6
    Purity: >99.50%

    PROTAC HK2 Degrader-1 is a proteolysis-targeting chimera (PROTAC) targeting hexokinase 2 (HK2), generated by conjugating the HK2 inhibitor Lonidamine with the CRBN E3 ubiquitin ligase ligand Thalidomide via a linker.

  • GC70717 structure
    GC70717Benitrobenrazide (Hexokinase 2 inhibitor 1)
    CAS: 2454676-05-0
    Purity: >98.00%

    Benitrobenrazide (Hexokinase 2 inhibitor 1) inhibits glycolysis by directly targeting HK2.

  • GC79709 structure
    GC79709HK2-IN-4
    CAS: 2748366-80-3
    Purity: >99.50%

    HK2-IN-4 is a selective hexokinase 2 ( HK2 ) inhibitor with an IC 50 value of 0.79 μM and a K d value of 0.41 μM.