GLPBio

Hippo Signaling

Hippo signaling is a conserved pathway for organ size control by modulating cell proliferation, apoptosis and tissue-specific stem cell regeneration. It is associated with carcinogenesis.

Products Related to Hippo Signaling(8)

  • GC14482 structure
    GC14482Verteporfin
    CAS: 129497-78-5
    Purity: >98.00%

    Verteporfin,a benzoporphyrin derivative monoacid ring A, is a photo-sensitizing agent for photodynamic therapy (PDT).

  • GC11245 structure
    GC11245XMU-MP-1
    CAS: 2061980-01-4
    Purity: >99.00%

    XMU-MP-1 is a reversible and selective inhibitor of MST1/2 kinase, with IC 50s of 71.1±12.9 nM and 38.1±6.9 nM for MST1 and MST2 respectively.

  • GC32914 structure
    GC32914EMT inhibitor-1
    CAS: 1638526-21-2
    Purity: >99.00%

    EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.

  • GC61410 structure
    GC61410I3MT-3
    CAS: 459420-09-8
    Purity: >98.00%

    I3MT-3 (HMPSNE) is a potent, selective, and cell-membrane permeable inhibitor of 3-Mercaptopyruvate sulfurtransferase (3MST) (IC50=2.7 μM).

  • GC69261 structure
    GC69261IHMT-MST1-58
    CAS: 2414484-25-4
    Purity: >99.00%

    IHMT-MST1-58 is an effective and selective inhibitor of STE20-like protein 1 kinase (MST1), with oral activity and an IC50 value of 23 nM. IHMT-MST1-58 can be used for research on type 1 or type 2 diabetes.

  • GC73860 structure
    GC73860JA310
    CAS: 3022928-90-8
    Purity: >99.50%

    JA310 is a highly selective MST3 kinase inhibitor.

  • GC81335 structure
    GC81335MST3-IN-1 TFA
    Purity: >99.00%

    MST3-IN-1 TFA (Compound LD-1) is a selective and orally active MST3 inhibitor, with an IC 50 of 122.4 nM.

  • GC81337 structure
    GC81337MR24 TFA
    Purity: >99.00%

    MR24 TFA, a G-5555 derivative, is a mammalian STE20-like ( MST ) kinase inhibitor.