Histone Deacetylation

Boc-Lys(Ac)-AMC is a substrate of histone deacetylases (HDACs).

BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC150 value (effective concentration able to increase the enzyme by 150%) of 1 uM.

Trapoxin A is a cyclotetrapeptide histone deacetylase (HDAC) inhibitor.

WT-161 is a potent and selective HDAC6 inhibitor with an IC50 of 0.40 nM.

Quisinostat dihydrochloride (JNJ-26481585 dihydrochloride) is an orally available, potent pan-HDAC inhibitor with IC50s of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM, and 0.37 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11, respectively. Quisinostat dihydrochloride has a broad spectrum antitumoral activity.

BRD3308 is a highly selective HDAC3 inhibitor with an IC50 of 54 nM.

A class I and II HDAC inhibitor

BRD4884 is an HDAC inhibitor with IC50 values of 29 nM, 62 nM, and 1.09 μM for HDAC1, 2, and 3, respectively.

HDAC3 Inhibitor (compound 5) is a potent and selective HDAC3 inhibitor, with an IC50 of 5.96 nM.

CAY10591 is a potent activator of Sirt1 and suppresses TNF-α in a dose-dependent manner.

CAY10398 is an inhibitor of histone deacetylase (HDAC1) with an IC50 value of 10 μM.

CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 μM).

Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access.

HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM).

Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access.

SAHA-d5 (SAHA-d5) is the deuterium labeled Vorinostat.

Trichostatin C is a glycosylated derivative of trichostatin A, the antifungal antibiotic that reversibly inhibits histone deacetylase.

Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM.

Valproic acid acyl-D-glucuronide is the major urinary metabolite of valproic acid.

An internal standard for the quantification of sodium butyrate

An HDAC6 inhibitor

A building block and synthetic intermediate

A building block

A prodrug form of all-trans retinoic acid and butyric acid