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IDT307

Catalog No.GC61837

IDT307, an analog of the organic cation MPP+, is a specific fluorescent substrate for DAT (fluorescent substrate APP+).

Products are for research use only. Not for human use. We do not sell to patients.

IDT307 Chemical Structure

Cas No.: 1141-41-9

Size Price Stock Qty
10mM (in 1mL DMSO)
$49.50
In stock
5 mg
$45.00
In stock
10 mg
$72.00
In stock
25 mg
$135.00
In stock
50 mg
$225.00
In stock
100 mg
$360.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

IDT307, an analog of the organic cation MPP+, is a specific fluorescent substrate for DAT (fluorescent substrate APP+)[1].

IDT307, an analog of the organic cation MPP+, is transported into CP epithelial cells at the apical (CSF-facing) membrane and sensitive to inhibition by the PMAT inhibitor quinine[1].IDT307 uptake and intracellular accumulation is greatly attenuated by ~70% in CP tissue from the Pmat knockout mouse[1].

References:
[1]. Tao Hu, et al. Molecular mechanisms of organic cation and anion transport at the blood‐CSF barrier. 01 April 2018.

Chemical Properties

Cas No. 1141-41-9 SDF
Canonical SMILES C[N+]1=CC=C(C2=CC=C(N(C)C)C=C2)C=C1.[I-]
Formula C14H17IN2 M.Wt 340.2
Solubility DMSO : 62.5 mg/mL (183.72 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.9394 mL 14.6972 mL 29.3945 mL
5 mM 0.5879 mL 2.9394 mL 5.8789 mL
10 mM 0.2939 mL 1.4697 mL 2.9394 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

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Average Rating: 5 ★★★★★ (Based on Reviews and 25 reference(s) in Google Scholar.)

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