Ifenprodil hemitartrate |
| Catalog No.GC10471 |
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
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Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Ifenprodil is a selective antagonist of NMDA receptors that contain NR2B subunits (IC50 = 0.3 µM) and displays 150-fold weaker activity at those bearing NR2C or NR2D subunits.[1] Ifenprodil also acts as a potent ligand at receptors for σ1, emopamil binding proteins, and their σ-like, fungal counterpart ERG2 (Kis = 2, 5, and 1 nM).[2] This compound has been described as an α-adrenergic vasodilator, but is also reported to constrict cerebrovascular smooth muscle in vitro (EC50 = 2.4 µM).[3]
Reference:
[1]. Bräuner-Osborne, H., Egebjerg, J., Nielsen, E.O., et al. Ligands for glutamate receptors: Design and therapeutic prospects J. Med. Chem. 43(14), 2609-2645 (2000).
[2]. Laggner, C., Schieferer, C., Fiechtner, B., et al. Discovery of high-affinity ligands of σ1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening J. Med Chem. 48(15), 4754-4764 (2005).
[3]. Young, A.R., Bouloy, M., Boussard, J.F., et al. Direct vascular effects of agents used in the pharmacotherapy of cerebrovascular disease on isolated cerebral vessels Journal of Cerebral Blood Flow and Metabolism 1(1), 117-128 (1981).
| Cas No. | 23210-58-4 | SDF | |
| Synonyms | N/A | ||
| Chemical Name | 4-((1R,2S)-2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl)phenol hemi((2R,3R)-2,3-dihydroxysuccinate) | ||
| Canonical SMILES | C[C@@](N1CCC(CC2=CC=CC=C2)CC1)([H])[C@@](O)([H])C3=CC=C(O)C=C3.C[C@@](N4CCC(CC5=CC=CC=C5)CC4)([H])[C@@](O)([H])C6=CC=C(O)C=C6.O[C@](C(O)=O)([H])[C@](O)([H])C(O)=O | ||
| Formula | C21H27NO2.½C4H6O6 | M.Wt | 400.49 |
| Solubility | DMF: 50 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 1 mg/ml | Storage | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
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