GLPBio

ITK

ITK (IL2-inducible T-cell kinase) is an intracellular tyrosine kinase that regulates adaptive immune response. It functions in T-cell development and differentiation.

Products Related to ITK(12)

  • GC10455 structure
    GC10455BMS-509744
    CAS: 439575-02-7
    Purity: >98%
  • GC12167 structure
    GC12167ITK inhibitor
    CAS: 439574-61-5
    Purity: >98%

    Potent ITK inhibitor

  • GC17630 structure
    GC17630PF 06465469
    CAS: 1407966-77-1
    Purity: >98.00%

    inhibitor of interleukin-2 inducible T cell kinase (ITK) and Bruton's tyrosine kinase (BTK)

  • GC30502 structure
    GC30502PRN694
    CAS: 1575818-46-0
    Purity: >99.00%

    PRN694 is an irreversible, highly selective and potent covalent interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) dual inhibitor with IC50s of 0.3 nM and 1.4 nM, respectively.

  • GC32053 structure
    GC32053GNE-4997
    CAS: 1705602-02-3
    Purity: >98%

    GNE-4997 is a potent and selective interleukin-2-inducible T-cell kinase (ITK) inhibitor with a Ki of 0.09 nM, and the correlation between the basicity of solubilizing elements in GNE-4997 and off-target antiproliferative effects reduces cytotoxicity.

  • GC34077 structure
    GC34077Vecabrutinib (SNS-062)
    CAS: 1510829-06-7
    Purity: >99.50%

    Vecabrutinib (SNS-062) (SNS-062) is a potent, noncovalent BTK and ITK inhibitor, with Kd values of 0.3 nM and 2.2 nM, respectively. Vecabrutinib (SNS-062) shows an IC50 of 24 nM for ITK.

  • GC36354 structure
    GC36354ITK inhibitor 2
    CAS: 1309784-09-5
    Purity: >98%

    ITK inhibitor 2 is a interleukin-2-inducible T-cell kinase (ITK) inhibitor extracted from patent WO2011065402A1, compound 4, with an IC50 of 2 nM.

  • GC50076 structure
    GC50076CTA 056
    CAS: 1265822-30-7
    Purity: >98%

    ITK inhibitor

  • GC50156 structure
    GC50156GSK 2250665A
    CAS: 1246030-96-5
    Purity: >98%

    Itk inhibitor

  • GC69183 structure
    GC69183GNE-9822
    CAS: 1557232-32-2
    Purity: >98%

    GNE-9822 is an orally effective selective inhibitor of ITK with a Ki value of 0.7 nM. GNE-9822 has good ADME properties and can be used for research on asthma.

  • GC81298 structure
    GC81298BSJ-05-037
    CAS: 2756388-01-7
    Purity: >99.50%

    BSJ-05-037 is an ITK PROTAC degrader that effectively targets and degrades ITK in T-cell lymphoma cell lines.

  • GC81322 structure
    GC81322PF-07245303
    CAS: 2655556-75-3
    Purity: >98%

    PF-07245303 is a ITK / TRK inhibitor.