JAB-3068

JAB-3068 (SHP2-IN-6) is a potent SHP2 inhibitor, extracted from patent WO2017211303A1, compound 7, has an IC₅₀ of 25.8 nM ^[1].

In Vitro, JAB-3068 (SHP2-IN-6) inhibits the proliferation of KYSE-520 cells with an IC₅₀ of 2.17 μM^[1].

References:
[1]. Cunbo Ma, et al. Novel heterocyclic derivatives useful as shp2 inhibitors. WO2017211303A1.