BCI-215 |
| カタログ番号GC39160 |
BCI-215 は、強力な腫瘍細胞選択的二重特異性 MAPK ホスファターゼ (DUSP-MKP) 阻害剤です。 BCI-215 は腫瘍細胞に対して細胞毒性を示しますが、正常細胞に対しては細胞毒性を示しません。
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Cas No.: 1245792-67-9
Sample solution is provided at 25 µL, 10mM.
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BCI-215 is a potent and tumor cell-selective dual specificity MAPK phosphatase (DUSP-MKP) inhibitor. BCI-215 has cytotoxicity for tumor cells but not normal cells[1][2].
[1]. Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15(10):1436-45. [2]. Kaltenmeier CT, et al. A Tumor Cell-Selective Inhibitor of Mitogen-Activated Protein Kinase Phosphatases Sensitizes Breast Cancer Cells to Lymphokine-Activated Killer Cell Activity. J Pharmacol Exp Ther. 2017 Apr;361(1):39-50.
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