CAY10606 |
| カタログ番号GC18877 |
5-リポキシゲナーゼ（5-LO）は、特定の白血球集団を中心にアラキドン酸からルコトリエン（LT）の合成を開始します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1159576-98-3
Sample solution is provided at 25 µL, 10mM.
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5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs) from arachidonic acid, primarily in certain leukocyte populations. CAY10606 is a potent, reversible inhibitor of 5-LO, both in cell-free assays (IC50 = 86 nM) and in intact neutrophils (IC50 = 230 nM). It prevents the production of LTs in whole blood, whether 5-LO is activated with the calcium ionophore A23187 (IC50 = 1.6 μM) or formyl peptide (fMLP) following priming with lipopolysaccharide (IC50 = 830 nM). In rats subjected to carrageenan-induced pleurisy, CAY10606 significantly reduces both LT biosynthesis and the inflammatory reaction.
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