Aspartyl-alanyl-diketopiperazine (Synonyms: DA-DKP) |
| カタログ番号GC35410 |
アスパルチル-アラニル-ジケトピペラジン (DA-DKP) は、ヒトアルブミンの N 末端からの切断と環化によって生成される免疫調節分子であり、T リンパ球アネルギーに関与する分子経路を介して炎症性免疫応答を調節することができます 。 .
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Cas No.: 110954-19-3
Sample solution is provided at 25 µL, 10mM.
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Aspartyl-alanyl-diketopiperazine (DA-DKP) is an immunomodulatory molecule generated by cleavage and cyclization from the N-terminus of human albumin and can modulate the inflammatory immune response through a molecular pathway implicated in T- lymphocyte anergy[1][2].
[1]. Bar-Or D, et al. Dipeptidyl peptidase IV activity in commercial solutions of human serum albumin. Anal Biochem. 2013 Oct 1;441(1):13-7. [2]. Shimonkevitz R, et al. A diketopiperazine fragment of human serum albumin modulates T-lymphocyte cytokine production through rap1. J Trauma. 2008 Jan;64(1):35-41.
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