Feglymycin |
| カタログ番号GC43659 |
フェグリマイシンは、抗菌および抗ウイルス活性を持つストレプトマイセスから最初に単離された13アミノ酸ペプチドです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 209335-49-9
Sample solution is provided at 25 µL, 10mM.
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Feglymycin is a 13-amino acid peptide originally isolated from Streptomyces that has antibacterial and antiviral activities. It is active against Gram-positive bacteria (MICs = 32-64 µg/ml) and inhibits HIV viral replication in H9 cells (IC50 = ~5 µM). Feglymycin is also active against clinical isolates of HIV-1 from clades A-D, A/E, and G (EC50s = 0.5-6.7 µM). It interacts with gp120 and inhibits HIV-1 NL4.3 binding to human soluble CD4 (EC50 = 4.4 µM) and to CD4+ SupT1 T cells by 74.5% when used at a concentration of 10.5 µM. Feglymycin inhibits the E. coli peptidoglycan biosynthesis enzymes MurA and MurC (Kis = 3.4 and 0.3 µM, respectively) in a noncompetitive manner.
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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