Harzianum A is a trichothecene fungal metabolite originally isolated from T. harzianum.1 It is cytotoxic to HeLa, MCF-7, and HT-1080 cells (IC50s = 5.07, 10.13, and 0.65 μg/ml, respectively) and exhibits antifungal activity against C. albicans and S. cerevisiae when used at a concentration of 100 μg/ml.1,2
References
1. Corley, D.G., Miller-Wideman, M., and Durley, R.C. Isolation and structure of harzianum A: A new trichothecene from Trichoderma harzianum. J. Nat. Prod. 57(3), 422-425 (1994).
2. Lee, H.B., Kim, Y., Jin, H.Z., et al. A new Hypocrea strain producing harzianum A cytotoxic to tumour cell lines. Lett. Appl. Microbiol. 40(6), 497-503 (2005).