Indirubin-3'-monoxime-5-sulphonic acid |
カタログ番号GC36312 |
インジルビン-3'-モノキシム-5-スルホン酸は、CDK1、CDK5、および GSK-3β の強力かつ選択的な阻害剤です。それぞれ 5 nM、7 nM、および 80 nM の IC50 で。
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Cas No.: 331467-05-1
Sample solution is provided at 25 µL, 10mM.
Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively[1]. CDK1|5 nM (IC50)|CDK5|7 nM (IC50)|GSK-3β|80 nM (IC50)
[1]. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors. J Biol Chem. 2001 Jan 5;276(1):251-60.
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