GR-14-3-3 stabilizer-1 is a molecular glue stabilizer for the protein-protein interaction between 14‑3‑3 and glucocorticoid receptor (GR), and functions by stabilizing the GR‑14‑3‑3 protein-protein interaction. GR-14-3-3 stabilizer-1 is applicable to research related to diseases such as tumors [1].
In Vitro, GR-14-3-3 stabilizer-1 (Compound 10) (100 μM) stabilizes the GR‑14‑3‑3ζ protein-protein interaction in fluorescence polarization (FP) biochemical assays, with a TE100 value of 2.3 [1].
References:
[1]. Perry M, et al. Rational discovery of molecular glues for the glucocorticoid receptor‑14‑3‑3 protein‑protein interaction starting with application of traditional hit‑finding methods. ChemRxiv, 2024.
In Vitro, GR-14-3-3 stabilizer-1 (Compound 10) (100 μM) stabilizes the GR‑14‑3‑3ζ protein-protein interaction in fluorescence polarization (FP) biochemical assays, with a TE100 value of 2.3 [1].
References:
[1]. Perry M, et al. Rational discovery of molecular glues for the glucocorticoid receptor‑14‑3‑3 protein‑protein interaction starting with application of traditional hit‑finding methods. ChemRxiv, 2024.