IACS-9571 hydrochloride (Synonyms: ASIS-P040 hydrochloride) |
| カタログ番号GC60925 |
IACS-9571 (ASIS-P040) 塩酸塩は、TRIM24 と BRPF1 の強力かつ選択的な阻害剤であり、TRIM24 の IC50 は 8 nM、TRIM24 と BRPF1 の Kds はそれぞれ 31 nM と 14 nM です。
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Cas No.: 2319611-93-1
Sample solution is provided at 25 µL, 10mM.
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IACS-9571 (ASIS-P040) hydrochloride is a potent and selective inhibitor of TRIM24 and BRPF1, with an IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively[1].
IACS-9571 Hydrochloride shows excellent cellular potency with EC50 of 50 nM. IACS-9571 Hydrochloride (1 μM) has potent activities against a panel of 32 bromodomains. IACS-9571 Hydrochloride is a selective dual TRIM24/BRPF1 inhibitor (Kd=1.3/2.1 nM) with 9- and 21-fold selectivity against BRPF2 and BRPF3, respectively. IACS-9571 Hydrochloride does not interact with the BET sub-family of bromodomains, displaying greater than 7700-fold selectivity versus BRD4 (1, 2) relative to TRIM24[1].
[1]. Palmer WS, et al. Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. J Med Chem. 2016 Feb 25;59(4):1440-54.
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