JHU 37160 |
| カタログ番号GC50682 |
JHU 37160 は強力な脳浸透性 DREADD アゴニストであり、HEK-293 細胞の hM3Dq および hM4Di DREADD の EC50 はそれぞれ 18.5 nM および 0.2 nM です。
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Cas No.: 2369979-68-8
Sample solution is provided at 25 µL, 10mM.
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High affinity and highly potent activator of hM3Dq and hM4Di DREADDs (Ki values are 1.9 nM and 3.6 nM for hM3Dq and hM4Di in vitro, respectively; EC50 values are 18.5 nM and 0.2 nM for hM3Dq and hM4Di in vitro, respectively). Displays approximately 25-fold higher affinity for hM4Di compared to DREADD agonist 21 . Selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites. Inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons, and increases hM3Dq-stimulated locomotion in rats expressing hM3Dq in TH-expressing neurons. Brain penetrant in mice, rats and non-human primates.
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
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