LGD-6972 |
| カタログ番号GC31343 |
LGD-6972 は、選択的かつ経口的に活性なグルカゴン受容体拮抗薬です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1207989-09-0
Sample solution is provided at 25 µL, 10mM.
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LGD-6972 is a glucagon receptor antagonist.
LGD-6972 has linear plasma pharmacokinetics consistent with once daily dosing that is comparable in healthy and T2DM subjects. Dose-dependent decreases in fasting plasma glucose are observed in all groups with a maximum of 3.15 mM (56.8 mg/dL) on day 14 in T2DM subjects. LGD-6972 also reduces plasma glucose in the postprandial state. Dose-dependent increases in fasting plasma glucagon are observed, but glucagon levels decrease and insulin levels increase after an oral glucose load in T2DM subjects. LGD-6972 is well tolerated at the doses tested without dose-related or clinically meaningful changes in clinical laboratory parameters. No subject experiences hypoglycaemia[1].
[1]. Vajda EG, et al. Pharmacokinetics and pharmacodynamics of single and multiple doses of the glucagon receptor antagonist LGD-6972 in healthy subjects and subjects with type 2 diabetes mellitus. Diabetes Obes Metab. 2017 Jan;19(1):24-32.
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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