MX69 |
| カタログ番号GC19257 |
MX69 は、がん治療に使用される MDM2/XIAP の阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1005264-47-0
Sample solution is provided at 25 µL, 10mM.
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MX69 is an inhibitor of MDM2/XIAP, used for cancer treatment.
MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. MX69 shows minimal inhibitory effect on normal human hematopoiesis in vitro and is very well tolerated in animal models. MX69-induced MDM2 downregulation results not only in inhibition of XIAP expression, but also in activation of p53, which contributes to cancer cell apoptosis in vitro[1].
MX69-induced MDM2 downregulation results in activation of p53 which contributes to inhibition of cancer cell proliferation in vivo[1].
References:
[1]. Gu L, et al. Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment. Cancer Cell. 2016 Oct 10;30(4):623-636
Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)
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