Pentetic acid (DTPA)はEDTA に似た構造を持つ強力なアミノポリカルボン酸キレート剤である[1]。Pentetic acidと金属イオンはしっかり結合し、安定している複合体を形成し、尿を通じて迅速に体外へ排出することで体内の有害な金属の滞留と毒性を軽減する[2]。Pentetic acidは主に放射性汚染の治療と医療画像の処理における造影剤として使用される[3-4]。
PAO1細菌ではPentetic acidはエラスターゼの分泌を大幅に阻害できる[5]。
References:
[1]. Knepper T P. Synthetic chelating agents and compounds exhibiting complexing properties in the aquatic environment[J]. TrAC Trends in Analytical Chemistry, 2003, 22(10): 708-724.
[2]. Sandal N, Mahar R, Sharma P. Optimizing Ca-DTPA/Zn-DTPA therapy for internal decorporation: transitioning from intravenous to oral route with insights on safety and toxicity[J]. Journal of Radiological Protection, 2025, 45(1): 011002.
[3]. Hussain A, Alajmi M F, Ganguly S. Pentetic acid derived dual purpose fluorescent carbon dots for pH responsive drug delivery and antioxidant proficiency[J]. Diamond and Related Materials, 2024, 145: 111101.
[4]. Capra R, Marcianò N, Vignolo L A, et al. Gadolinium—Pentetic Acid Magnetic Resonance Imaging in Patients With Relapsing Remitting Multiple Sclerosis[J]. Archives of neurology, 1992, 49(7): 687-689.
[5]. Gi M, Jeong J, Lee K, et al. A drug-repositioning screening identifies pentetic acid as a potential therapeutic agent for suppressing the elastase-mediated virulence of Pseudomonas aeruginosa[J]. Antimicrobial agents and chemotherapy, 2014, 58(12): 7205-7214.