Physalin B |
| カタログ番号GC61183 |
ケープ グーズベリーの主要な活性ステロイド成分の 1 つであるフィサリン B は、細胞周期の停止を誘導し、p53 依存性アポトーシス経路を調節することにより、乳癌細胞のアポトーシスを引き起こします。フィサリン B は、ユビキチン-プロテアソーム経路を阻害し、in vitro でヒト結腸癌細胞の不完全なオートファジー応答を誘導します。
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Cas No.: 23133-56-4
Sample solution is provided at 25 µL, 10mM.
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Physalin B, one of the major active steroidal constituents of Cape gooseberry, induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway. Physalin B inhibits the ubiquitin-proteasome pathway and induces incomplete autophagic response in human colon cancer cells in vitro[1][2].
[1]. Wang A, et al. Physalin B induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway. Biomed Pharmacother. 2018;101:334-341. [2]. Ma YM, et al. Physalin B not only inhibits the ubiquitin-proteasome pathway but also induces incomplete autophagic response in human colon cancer cells in vitro. Acta Pharmacol Sin. 2015;36(4):517-527.
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