(±)5(6)-DiHET lactone (Synonyms: (±)5,6DiHETrE lactone) |
| カタログ番号GC40437 |
5,6-DiHETラクトンは、5,6-EETおよび5,6-DiHETのラクトン化された形態です。
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Cas No.: 213126-92-2
Sample solution is provided at 25 µL, 10mM.
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5,6-DiHET lactone is a lactonized form of 5,6-EET and 5,6-DiHET. In solution, 5(6)-EET degrades into 5(6)-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. 5,6-DiHET potently induces vasodilation of isolated canine coronary arterioles, with 41 and 100% inhibition occurring at 0.01 and 100 pM, respectively. It also induces vasodilation in isolated human microvessels and increases intracellular calcium levels in a dose-dependent manner, an effect that can be blocked by the nitric oxide scavenger L-NAME .
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