Pyk2-IN-2 (compound 13j) is an inhibitor of Pyk2 with an IC50 of FAK kinase of 0.608 μM.
Pyk2-IN-2 (compound 13j) has an IC50 of 55 nM against PYK2 cells[1].
The HLM blood clearance of Pyk2-IN-2 (compound 13j) is 31 mL/min/kg[1].Pharmacokinetic Analysis in male Wistar-Han rats[1]
References:
[1]. Bhattacharya SK, et al. Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7523-9.